Universität zu Köln

Hess, Martin E. and Bruening, Jens C. (2014). The fat mass and obesity-associated (FTO) gene: Obesity and beyond? Biochim. Biophys. Acta-Mol. Basis Dis., 1842 (10). S. 2039 - 2048. AMSTERDAM: ELSEVIER. ISSN 1879-260X

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Abstract

Genome wide association studies undoubtedly linked variants of the fat mass and obesity-associated protein (FTO) to obesity. To date, however, knowledge on the mechanisms coupling variants in the intron of the FTO gene to its expression or enzymatic activity to alter metabolism remains scarce. Until recently, the investigation of the molecular function of FTO had not led to conclusive results concerning the 'where', 'when' and 'how' of FTO activity. Finally, since FTO was identified as a RNA modifying enzyme, demethylating N6-methyladenosine on single stranded RNA, novel understanding of the molecular function is gathered. These and other studies suggest the requirement for a further reaching approach to further investigate FTO function, since the phenotype of aberrant FTO function may encompass more than just obesity. Taking these new insights and translating them into appropriate paradigms for functional research in humans may lead to a deeper understanding of the human physiology and disease. This article is part of a Special Issue entitled. From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hess, Martin E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-427309
DOI:	10.1016/j.bbadis.2014.01.017
Journal or Publication Title:	Biochim. Biophys. Acta-Mol. Basis Dis.
Volume:	1842
Number:	10
Page Range:	S. 2039 - 2048
Date:	2014
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1879-260X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENERGY-INTAKE; FOOD-INTAKE; MESSENGER-RNA; VARIANT; MOUSE; POLYMORPHISMS; EXPRESSION; CHILDHOOD; RS9939609; REVEALS Multiple languages Biochemistry & Molecular Biology; Biophysics; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42730