Hartmann, Sylvia, Eichenauer, Dennis A., Pluetschow, Annette, Mottok, Anja ORCID: 0000-0003-3125-0494, Bob, Roshanak, Koch, Karoline, Bernd, Heinz-Wolfram, Cogliatti, Sergio, Hummel, Michael, Feller, Alfred C., Ott, German, Moeller, Peter, Rosenwald, Andreas, Stein, Harald, Hansmann, Martin-Leo, Engert, Andreas and Klapper, Wolfram (2014). Histopathological features and their prognostic impact in nodular lymphocyte-predominant Hodgkin lymphoma - a matched pair analysis from the German Hodgkin Study Group (GHSG). Br. J. Haematol., 167 (2). S. 238 - 243. HOBOKEN: WILEY-BLACKWELL. ISSN 1365-2141

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Abstract

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma entity. We performed a matched-pair analysis to evaluate the prognostic impact of several histopathological features in this distinct Hodgkin lymphoma subtype. Lymph node samples of NLPHL patients were tested for CD15, IgD, phosphorylated STAT6, ICOS and Epstein-Barr virus status of the malignant lymphocyte-predominant cells as well as epithelioid cell clusters and activated T cells in the microenvironment. None of these features was associated with a particular clinical outcome. However, patients presenting with epithelioid cell clusters showed a non-significant trend towards a lower relapse rate, justifying further evaluation of this marker.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hartmann, SylviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eichenauer, Dennis A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pluetschow, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mottok, AnjaUNSPECIFIEDorcid.org/0000-0003-3125-0494UNSPECIFIED
Bob, RoshanakUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koch, KarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernd, Heinz-WolframUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cogliatti, SergioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hummel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feller, Alfred C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ott, GermanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moeller, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenwald, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stein, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansmann, Martin-LeoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engert, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klapper, WolframUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-427319
DOI: 10.1111/bjh.12997
Journal or Publication Title: Br. J. Haematol.
Volume: 167
Number: 2
Page Range: S. 238 - 243
Date: 2014
Publisher: WILEY-BLACKWELL
Place of Publication: HOBOKEN
ISSN: 1365-2141
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CELLS; RITUXIMAB; PHENOTYPE; SOCS1Multiple languages
HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/42731

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