Universität zu Köln

Schroeck, Andreas, Goeke, Friederike, Wagner, Patrick, Bode, Maike, Franzen, Alina, Huss, Sebastian, Agaimy, Abbas, Ihrler, Stephan, Kirsten, Robert, Kristiansen, Glen, Bootz, Friedrich, Lengerke, Claudia ORCID: 0000-0001-5442-2805 and Perner, Sven (2014). Fibroblast growth factor receptor-1 as a potential therapeutic target in sinonasal cancer. Head Neck-J. Sci. Spec. Head Neck, 36 (9). S. 1253 - 1258. HOBOKEN: WILEY. ISSN 1097-0347

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Abstract

Background. Despite multimodal treatment, sinonasal malignancies have an unfavorable prognosis. The purpose of this study was to elucidate if these tumors harbor amplifications of the fibroblast growth factor receptor 1 (FGFR1) gene, which has recently been identified as a potential therapeutic target in squamous cell lung cancer. Methods. One hundred twelve primary tumors (including squamous cell carcinoma [SCC], carcinoma associated with an inverted papilloma, sinonasal undifferentiated carcinoma [SNUC], adenocarcinoma, adenoid cystic carcinoma [ACC], esthesioneuroblastoma, and 9 corresponding lymph node metastases) were assessed by fluorescence in situ hybridization (FISH) for FGFR1 copy number status. Human papillomavirus (HPV) status was assessed by p16 immunohistochemical as a surrogate marker. Results. FGFR1 amplification was found in subsets of sinonasal SCCs (20%), carcinomas associated with an inverted papilloma (33%), and SNUCs (5%). In all cases, metastatic tumor samples shared the same FGFR1 amplification status as the corresponding primary tumor tissue. None of the FGFR1-amplified tumors expressed p16. Conclusion. FGFR1 amplification represents a potential molecular target in a subset of patients with sinonasal cancer. (C) 2014 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schroeck, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Goeke, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Bode, Maike UNSPECIFIED UNSPECIFIED UNSPECIFIED Franzen, Alina UNSPECIFIED UNSPECIFIED UNSPECIFIED Huss, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Agaimy, Abbas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ihrler, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirsten, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Kristiansen, Glen UNSPECIFIED UNSPECIFIED UNSPECIFIED Bootz, Friedrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Lengerke, Claudia UNSPECIFIED orcid.org/0000-0001-5442-2805 UNSPECIFIED Perner, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-430599
DOI:	10.1002/hed.23443
Journal or Publication Title:	Head Neck-J. Sci. Spec. Head Neck
Volume:	36
Number:	9
Page Range:	S. 1253 - 1258
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0347
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMAS; HUMAN-PAPILLOMAVIRUS DNA; FGFR1 AMPLIFICATION; GENE AMPLIFICATION; ASSOCIATION; EXPRESSION; BENIGN Multiple languages Otorhinolaryngology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43059