Universität zu Köln

Schmidt, Daniel, Kollan, Christian, Faetkenheuer, Gerd, Schuelter, Eugen, Stellbrink, Hans-Juergen, Noah, Christian, Jensen, Bjoern-Erik Ole, Stoll, Matthias, Bogner, Johannes R., Eberle, Josef, Meixenberger, Karolin, Kuecherer, Claudia, Hamouda, Osamah and Bartmeyer, Barbara (2014). Estimating Trends in the Proportion of Transmitted and Acquired HIV Drug Resistance in a Long Term Observational Cohort in Germany. PLoS One, 9 (8). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Objective: We assessed trends in the proportion of transmitted (TDR) and acquired (ADR) HIV drug resistance and associated mutations between 2001 and 2011 in the German ClinSurv-HIV Drug Resistance Study. Method: The German ClinSurv-HIV Drug Resistance Study is a subset of the German ClinSurv-HIV Cohort. For the ClinSurv-HIV Drug Resistance Study all available sequences isolated from patients in five study centres of the long term observational ClinSurv-HIV Cohort were included. TDR was estimated using the first viral sequence of antiretroviral treatment (ART) naive patients. One HIV sequence/patient/year of ART experienced patients was considered to estimate the proportion of ADR. Trends in the proportion of HIV drug resistance were calculated by logistic regression. Results: 9,528 patients were included into the analysis. HIV-sequences of antiretroviral naive and treatment experienced patients were available from 34% (3,267/9,528) of patients. The proportion of TDR over time was stable at 10.4% (95% CI 9.1-11.8; p (for trend) = 0.6; 2001-2011). The proportion of ADR among all treated patients was 16%, whereas it was high among those with available HIV genotypic resistance test (64%; 1,310/2,049 sequences; 95% CI 62-66) but declined significantly over time (OR 0.8; 95% CI 0.77-0.83; p (for trend)<0.001; 2001-2011). Viral load monitoring subsequent to resistance testing was performed in the majority of treated patients (96%) and most of them (67%) were treated successfully. Conclusions: The proportion of TDR was stable in this study population. ADR declined significantly over time. This decline might have been influenced by broader resistance testing, resistance test guided therapy and the availability of more therapeutic options and not by a decline in the proportion of TDR within the study population.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmidt, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Kollan, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Faetkenheuer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuelter, Eugen UNSPECIFIED UNSPECIFIED UNSPECIFIED Stellbrink, Hans-Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Noah, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Jensen, Bjoern-Erik Ole UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoll, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Bogner, Johannes R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eberle, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Meixenberger, Karolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuecherer, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamouda, Osamah UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartmeyer, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-431868
DOI:	10.1371/journal.pone.0104474
Journal or Publication Title:	PLoS One
Volume:	9
Number:	8
Date:	2014
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Mathematics and Computer Science > Institute of Computer Science
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INFECTED PATIENTS; MUTATIONS; PREVALENCE; TRANSMISSION; ASSOCIATION; INHIBITORS Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/43186