Universität zu Köln

Lehmann, Helmar C., Zhang, Gang and Sheikh, Kazim A. (2014). New and emerging treatments of Guillain-Barre syndrome. Exp. Opin. Orphan Drugs, 2 (8). S. 817 - 830. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 2167-8707

Full text not available from this repository.

Abstract

Introduction: Guillain-Barre syndrome (GBS) is an acute inflammatory monophasic peripheral neuropathy of autoimmune origin. Although there are effective immunomodulatory treatments available for GBS, a substantial number of patients are left with residual neurological deficits. Nowadays, it is accepted that autoantibodies against gangliosides are pathogenic effectors in subtypes of GBS. It has been demonstrated that these autoantibodies can not only induce damage to intact nerve fibers but also inhibit axon regeneration after nerve injury, which might potentially account for the slow/poor recovery and prognosis in some GBS patients. Areas covered: Recent insights into the pathogenesis of GBS led to the recognition of promising targets for future development of novel therapies. This review discusses potentially new and emerging treatments that stemmed from preclinical studies. These emerging treatments can be grouped into immunomodulatory/anti-inflammatory and neuroprotective categories including inhibition of complement activation, enhanced clearance of autoantibodies against gangliosides by blocking neonatal Fc receptor, modulation of Fc gamma receptors-mediated inflammation by sialylated intravenous Ig (IVIg) or IVIg-mimics and strategies for neuroprotection/enhancing regeneration by erythropoietin. Expert opinion: New and emerging treatments offer promise to optimize therapy for GBS patients, especially those who are refractory to currently used treatment modalities in the short term and those who are at higher risk of developing permanent sequelae (neurological deficits) in the long run.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lehmann, Helmar C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Gang UNSPECIFIED UNSPECIFIED UNSPECIFIED Sheikh, Kazim A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-432604
DOI:	10.1517/21678707.2014.925393
Journal or Publication Title:	Exp. Opin. Orphan Drugs
Volume:	2
Number:	8
Page Range:	S. 817 - 830
Date:	2014
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	2167-8707
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILLER-FISHER-SYNDROME; EXPERIMENTAL ALLERGIC NEURITIS; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; INCREASES ERYTHROCYTE EXPRESSION; EXPERIMENTAL AUTOIMMUNE NEURITIS; CAMPYLOBACTER-JEJUNI INFECTION; PERIPHERAL-NERVE INJURY; MOTOR AXONAL NEUROPATHY; IGG ANTI-GM1 ANTIBODIES; NEONATAL FC-RECEPTOR Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43260