Universität zu Köln

von Morgenstern, Sophie Beyer, Becker, Ingrid ORCID: 0000-0001-5829-3553 and Sinzig, Judith ORCID: 0000-0002-3693-3318 (2014). Improvement of facial affect recognition in children and adolescents with attention-deficit/hyperactivity disorder under methylphenidate. Acta Neuropsychiatr., 26 (4). S. 202 - 209. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 1601-5215

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Abstract

Introduction and Hypothesis: Some authors draw a connection between the dopaminergic pathways and emotional perception. The present study is based on that association and addresses the question whether methylphenidate and the resulting amelioration of the disturbed dopamine metabolism lead to an improvement of the facial affect recognition abilities in children with attention-deficit/hyperactivity disorder (ADHD). Methods: A computer test was conducted on 21 participants, aged 7-14 years and with a diagnosis of ADHD - some with comorbid oppositional defiant disorder - conducted the FEFA (Frankfurt Test and Training of Facial Affect), a computer test to examine their facial affect recognition abilities. It consists of two subtests, one with faces and one with eye pairs. All participants were tested in a double-blind cross-over study, once under placebo and once under methylphenidate. Results and Discussion: The collected data showed that methylphenidate leads to amelioration of facial affect recognition abilities, but not on a significant level. Reasons for missing significance may be the small sample size or the fact that there exists some overlapping in cerebral connections and metabolic pathways of the site of action of methylphenidate and the affected dopaminergic areas in ADHD. However, consistent with the endophenotype concept, certain gene locations of the dopaminergic metabolism as both an aetiological factor for ADHD and the deficient facial affect recognition abilities with these individuals were considered. Consulting current literature they were found to be not concordant. Therefore, we conclude that the lacking significance of the methylphenidate affect on facial affect recognition is based on this fact.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Morgenstern, Sophie Beyer UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Ingrid UNSPECIFIED orcid.org/0000-0001-5829-3553 UNSPECIFIED Sinzig, Judith UNSPECIFIED orcid.org/0000-0002-3693-3318 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-432710
DOI:	10.1017/neu.2013.55
Journal or Publication Title:	Acta Neuropsychiatr.
Volume:	26
Number:	4
Page Range:	S. 202 - 209
Date:	2014
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	NEW YORK
ISSN:	1601-5215
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEFICIT HYPERACTIVITY DISORDER; HIGH-FUNCTIONING ADULTS; EMOTIONAL EXPRESSIONS; ENDOPHENOTYPE CONCEPT; ADHD; DOPAMINE; AUTISM; MIND; GENE; PREVALENCE Multiple languages Neurosciences; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43271