Universität zu Köln

Masli, Sharmila, Sheibani, Nader ORCID: 0000-0003-2723-9217, Cursiefen, Claus and Zieske, James ORCID: 0000-0002-3730-6180 (2014). Matricellular Protein Thrombospondins: Influence on Ocular Angiogenesis, Wound Healing and Immuneregulation. Curr. Eye Res., 39 (8). S. 759 - 775. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1460-2202

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Abstract

Thrombospondins are a family of large multi-domain glycoproteins described as matricelluar proteins based on their ability to interact with a broad range of receptors, matrix molecules, growth factors or proteases, and to modulate array of cellular functions including intracellular signaling, proliferation and migration. Two members of the thrombospondin family, thrombospondin 1 (TSP-1) and thrombospondin 2 (TSP-2) are studied extensively to determine their structure and function. While expressed at low levels in normal adult tissues, their increased expression is seen predominantly in response to cellular perturbations. Despite structural similarities, a notable functional difference between TSP-1 and TSP-2 includes the ability of former to activate of latent TGF-beta and its competitive inhibition by the latter. Both these thrombospondins are reported to play important roles in TGF-b rich ocular environment with most reports related to TSP-1. They are expressed by many ocular cell types and detectable in the aqueous and vitreous humor. TSP-1 and TSP-2 influence many cellular interactions in the eye such as angiogenesis, cell migration, wound healing, TGF-beta activation and regulation of inflammatory immune responses. Together, these processes are known to contribute to the immune privilege status of the eye. Emerging roles of TSP-1 and TSP-2 in ocular functions and pathology are reviewed here.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Masli, Sharmila UNSPECIFIED UNSPECIFIED UNSPECIFIED Sheibani, Nader UNSPECIFIED orcid.org/0000-0003-2723-9217 UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Zieske, James UNSPECIFIED orcid.org/0000-0002-3730-6180 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-432734
DOI:	10.3109/02713683.2013.877936
Journal or Publication Title:	Curr. Eye Res.
Volume:	39
Number:	8
Page Range:	S. 759 - 775
Date:	2014
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	1460-2202
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH-FACTOR-BETA; RETINAL VASCULAR DEVELOPMENT; LATENCY-ASSOCIATED PEPTIDE; EPITHELIUM-DERIVED FACTOR; IMMUNE PRIVILEGE; CELL-MIGRATION; UP-REGULATION; TGF-BETA; ENDOTHELIAL-CELLS; NATURAL INHIBITOR Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43273