Universität zu Köln

Schulte-Ruether, Martin, Greimel, Ellen, Piefke, Martina, Kamp-Becker, Inge, Remschmidt, Helmut, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Herpertz-Dahlmann, Beate and Konrad, Kerstin ORCID: 0000-0001-9039-2615 (2014). Age-dependent changes in the neural substrates of empathy in autism spectrum disorder. Soc. Cogn. Affect. Neurosci., 9 (8). S. 1118 - 1127. OXFORD: OXFORD UNIV PRESS. ISSN 1749-5024

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Abstract

In typical development, empathic abilities continue to refine during adolescence and early adulthood. Children and adolescents with autism spectrum disorders (ASD) show deficits in empathy, whereas adults with ASD may have developed compensatory strategies. We aimed at comparing developmental trajectories in the neural mechanisms underlying empathy in individuals with ASD and typically developing control (TDC) subjects. Using an explicit empathizing paradigm and functional magnetic resonance imaging, 27 participants with ASD and 27 TDC aged 12-31 years were investigated. Participants were asked to empathize with emotional faces and to either infer the face's emotional state (other-task) or to judge their own emotional response (self-task). Differential age-dependent changes were evident during the self-task in the right dorsolateral prefrontal cortex, right medial prefrontal cortex, right inferior parietal cortex, right anterior insula and occipital cortex. Age-dependent decreases in neural activation in TDC were paralleled by either increasing or unchanged age-dependent activation in ASD. These data suggest ASD-associated deviations in the developmental trajectories of self-related processing during empathizing. In TDC, age-dependent modulations of brain areas may reflect the 'fine-tuning' of cortical networks by reduction of task-unspecific brain activity. Increased age-related activation in individuals with ASD may indicate the development of compensatory mechanisms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schulte-Ruether, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Greimel, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED Piefke, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamp-Becker, Inge UNSPECIFIED UNSPECIFIED UNSPECIFIED Remschmidt, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Herpertz-Dahlmann, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Konrad, Kerstin UNSPECIFIED orcid.org/0000-0001-9039-2615 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-433503
DOI:	10.1093/scan/nst088
Journal or Publication Title:	Soc. Cogn. Affect. Neurosci.
Volume:	9
Number:	8
Page Range:	S. 1118 - 1127
Date:	2014
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1749-5024
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ASPERGER-SYNDROME; MIRROR NEURON; BRAIN; MIND; CHILDREN; SELF; MECHANISMS; ADULTS; INSULA; REPRESENTATION Multiple languages Neurosciences; Psychology; Psychology, Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43350