Universität zu Köln

Jansen, Christian, Eischeid, Hannah, Goertzen, Jan, Schierwagen, Robert ORCID: 0000-0002-2195-3666, Anadol, Evrim, Strassburg, Christian P., Sauerbruch, Tilman, Odenthal, Margarete and Trebicka, Jonel ORCID: 0000-0002-7028-3881 (2014). The Role of miRNA-34a as a Prognostic Biomarker for Cirrhotic Patients with Portal Hypertension Receiving TIPS. PLoS One, 9 (7). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background-Circulating miRNA-34a is increased in blood of patients with different liver diseases when compared to healthy controls. However, the origin of miRNA-34a and its possible relationship with hemodynamics and outcome in cirrhotic patients with portal hypertension is unknown. We analyzed the levels of miRNA-34a in cirrhotic patients with severe portal hypertension. Methods: We included 60 cirrhotic patients receiving TIPS for prevention of rebleeding and/or therapy-refractory ascites. miRNA-34a levels were measured using qPCR and normalized by SV-40 in the portal and hepatic venous blood of these patients taken at TIPS procedure. Hemodynamic and clinical parameters were assessed before TIPS and during follow-up. Results: Levels of miRNA-34a were higher in the hepatic vein than in the portal vein. Circulating miRNA-34a in the hepatic vein correlated with ALT, CHE and sodium excretion after TIPS. miRNA-34a showed no correlation with portal pressure, but its levels in the portal vein correlated inversely with the congestion index. Interestingly, the levels of miRNA-34a in the portal and hepatic vein showed inverse correlation with arterial pressure. Furthermore, levels of miRNA-34a in the hepatic vein had a predictive value for survival, but MELD, creatinine at short-time follow-up 14 days after TIPS-insertion and portal pressure after TIPS performed better. Conclusion: This study demonstrates for the first time, that miRNA-34a may originate to a large extent from the liver. Even though higher levels of miRNA-34a are possibly associated with better survival at long-term follow-up in cirrhotic patients with severe portal hypertension receiving TIPS, classical prognostic parameters predict the survival better.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jansen, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Eischeid, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Goertzen, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schierwagen, Robert UNSPECIFIED orcid.org/0000-0002-2195-3666 UNSPECIFIED Anadol, Evrim UNSPECIFIED UNSPECIFIED UNSPECIFIED Strassburg, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sauerbruch, Tilman UNSPECIFIED UNSPECIFIED UNSPECIFIED Odenthal, Margarete UNSPECIFIED UNSPECIFIED UNSPECIFIED Trebicka, Jonel UNSPECIFIED orcid.org/0000-0002-7028-3881 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-433667
DOI:	10.1371/journal.pone.0103779
Journal or Publication Title:	PLoS One
Volume:	9
Number:	7
Date:	2014
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTRAHEPATIC PORTOSYSTEMIC SHUNT; NONALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; NATURAL-HISTORY; HEPATOCELLULAR-CARCINOMA; CIRCULATING MICRORNAS; MIR-34A; STEATOHEPATITIS; VEIN; PATHOPHYSIOLOGY Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43366