Ukken, Fiona Paul, Aprill, Imola, JayaNandanan, N. and Leptin, Maria ORCID: 0000-0001-7097-348X (2014). Slik and the Receptor Tyrosine Kinase Breathless Mediate Localized Activation of Moesin in Terminal Tracheal Cells. PLoS One, 9 (7). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

A key element in the regulation of subcellular branching and tube morphogenesis of the Drosophila tracheal system is the organization of the actin cytoskeleton by the ERM protein Moesin. Activation of Moesin within specific subdomains of cells, critical for its interaction with actin, is a tightly controlled process and involves regulatory inputs from membrane proteins, kinases and phosphatases. The kinases that activate Moesin in tracheal cells are not known. Here we show that the Sterile-20 like kinase Slik, enriched at the luminal membrane, is necessary for the activation of Moesin at the luminal membrane and regulates branching and subcellular tube morphogenesis of terminal cells. Our results reveal the FGF-receptor Breathless as an additional necessary cue for the activation of Moesin in terminal cells. Breathless-mediated activation of Moesin is independent of the canonical MAP kinase pathway.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ukken, Fiona PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aprill, ImolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
JayaNandanan, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leptin, MariaUNSPECIFIEDorcid.org/0000-0001-7097-348XUNSPECIFIED
URN: urn:nbn:de:hbz:38-433698
DOI: 10.1371/journal.pone.0103323
Journal or Publication Title: PLoS One
Volume: 9
Number: 7
Date: 2014
Publisher: PUBLIC LIBRARY SCIENCE
Place of Publication: SAN FRANCISCO
ISSN: 1932-6203
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EZRIN/RADIXIN/MOESIN ERM PROTEINS; TUMOR-SUPPRESSOR PROTEIN; BINDING-SITE; BRANCHING MORPHOGENESIS; ACTIN CYTOSKELETON; GENETIC-CONTROL; EPITHELIAL INTEGRITY; APICAL MEMBRANE; FERM DOMAIN; DROSOPHILAMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/43369

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