Universität zu Köln

Mathys, Christian, Hoffstaedter, Felix ORCID: 0000-0001-7163-3110, Caspers, Julian, Caspers, Svenja ORCID: 0000-0001-5083-4669, Suedmeyer, Martin, Grefkes, Christian ORCID: 0000-0002-1656-720X, Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 and Langner, Robert ORCID: 0000-0002-3237-001X (2014). An age-related shift of resting-state functional connectivity of the subthalarnic nucleus: a potential mechanism for compensating motor performance decline in older adults. Front. Aging Neurosci., 6. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1663-4365

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Abstract

Healthy aging is associated with decline in basic motor functioning and higher motor control. Here, we investigated age-related differences in the brain-wide functional connectivity (FC) pattern of the subthalamic nucleus (STN), which plays an important role in motor response control. As earlier studies revealed functional coupling between STN and basal ganglia, which both are known to influence the conservativeness of motor responses on a superordinate level, we tested the hypothesis that STN FC with the striatum becomes dysbalanced with age. To this end, we performed a seed-based resting-state analysis of fMRI data from 361 healthy adults (mean age: 41.8, age range: 18-85) using bilateral STN as the seed region of interest. Age was included as a covariate to identify regions showing age-related changes of FC with the STN seed. The analysis revealed positive FC of the STN with several previously described subcortical and cortical regions like the anterior cingulate and sensorimotor cortex, as well as not-yet reported regions including central and posterior insula. With increasing age, we observed reduced positive FC with caudate nucleus, thalamus, and insula as well as increased positive FC with sensorimotor cortex and putamen. Furthermore, an age-related reduction of negative FC was found with precuneus and posterior cingulate cortex. We suggest that this reduced de-coupling of brain areas involved in self-relevant but motor-unrelated cognitive processing (i.e. precuneus and posterior cingulate cortex) from the STN motor network may represent a potential mechanism behind the age-dependent decline in motor performance. At the same time, older adults appear to compensate for this decline by releasing superordinate motor control areas, in particular caudate nucleus and insula, from STN interference while increasing STN-mediated response control over lower level motor areas like sensorimotor cortex and putamen.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mathys, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffstaedter, Felix UNSPECIFIED orcid.org/0000-0001-7163-3110 UNSPECIFIED Caspers, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Caspers, Svenja UNSPECIFIED orcid.org/0000-0001-5083-4669 UNSPECIFIED Suedmeyer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED Langner, Robert UNSPECIFIED orcid.org/0000-0002-3237-001X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-433745
DOI:	10.3389/fnagi.2014.00178
Journal or Publication Title:	Front. Aging Neurosci.
Volume:	6
Date:	2014
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1663-4365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN PARIETAL OPERCULUM; BASAL GANGLIA; PARKINSONS-DISEASE; CYTOARCHITECTONIC AREAS; PROBABILISTIC MAPS; STEREOTAXIC SPACE; CINGULATE CORTEX; BRAIN; STIMULATION; PARCELLATION Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43374