Universität zu Köln

Kempf, Werner ORCID: 0000-0002-6552-8629, Kazakov, Dmitry V., Scheidegger, Paul E., Schlaak, Max and Tantcheva-Poor, Iliana (2014). Two Cases of Primary Cutaneous Lymphoma With a gamma/delta plus Phenotype and an Indolent Course: Further Evidence of Heterogeneity of Cutaneous gamma/delta plus T-Cell Lymphomas. Am. J. Dermatopathol., 36 (7). S. 570 - 578. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1533-0311

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Abstract

Cutaneous gamma/delta+ T-cell lymphoma (CGD-TCL) is a rare but aggressive lymphoma associated with a poor prognosis in most patients. The clinicopathological spectrum is variable including predominantly epidermotropic infiltrates manifesting with patches and plaques or tumors with dermal and/or subcutaneous infiltrates. The diagnosis of CGD-TCL requires the demonstration of a gamma/delta+ phenotype by immunohistochemistry. We report 2 patients with epidermotropic cutaneous T-cell lymphomas displaying a gamma/delta+ phenotype, but exhibiting an indolent course. In one patient, the clinical presentation was similar to mycosis fungoides in patch and plaque stage, but recurrent blister formation within the lesions was observed accompanied by fever and arthralgias, whereas the second patient presented with 2 localized erosive plaques on the left temple and dense epidermotropic and dermal diffuse and folliculotropic infiltrates of atypical small-to-medium-sized lymphocytes. These cases corroborate the view that expression of a gamma/delta+ phenotype in cutaneous T-cell lymphomas per se does not portend a worse prognosis and that CGD-TCL may represent a clinically and prognostically heterogeneous group.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kempf, Werner UNSPECIFIED orcid.org/0000-0002-6552-8629 UNSPECIFIED Kazakov, Dmitry V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheidegger, Paul E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlaak, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Tantcheva-Poor, Iliana UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-434676
DOI:	10.1097/DAD.0000000000000029
Journal or Publication Title:	Am. J. Dermatopathol.
Volume:	36
Number:	7
Page Range:	S. 570 - 578
Date:	2014
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1533-0311
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GAMMA-DELTA; MYCOSIS-FUNGOIDES; PAPULOSIS; CLASSIFICATION; EXPRESSION; RECEPTOR; VARIANT; SPECTRUM; PD-1 Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43467