Universität zu Köln

Bucher, Franziska, Adler, Werner ORCID: 0000-0001-9791-5407, Lehmann, Helmar C., Hos, Deniz, Steven, Philipp, Cursiefen, Claus and Heindl, Ludwig M. (2014). Corneal nerve alterations in different stages of Fuchs' endothelial corneal dystrophy: an in vivo confocal microscopy study. Graefes Arch. Clin. Exp. Ophthalmol., 252 (7). S. 1119 - 1127. NEW YORK: SPRINGER. ISSN 1435-702X

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Abstract

To analyze potential alterations in corneal nerve morphology and function in different stages of Fuchs' endothelial corneal dystrophy (FECD). Thirty eyes with FECD underwent in vivo confocal microscopy using the Heidelberg Retina Tomograph II (HRT II; Heidelberg Engineering, Heidelberg, Germany) and the Rostock Cornea Module (RCM) to quantify the morphology of the central subbasal corneal nerve plexus (total nerve length, total nerve number, number of main nerve trunks, number of nerve branches) as well as esthesiometry (using the Cochet-Bonnet esthesiometer) of the central cornea to determine central corneal sensation as a measure of nerve function. Findings were correlated with an age-matched control group of 30 healthy individuals. Comparisons to biomicroscopical stage of FECD, visual acuity and central corneal thickness were performed using Spearman correlation. Depending on slit-lamp examination, all 30 eyes were classified into FECD stage 1-4 (stage 1: six eyes; stage 2: 15 eyes; stage 3: six eyes; stage 4: three eyes). Total nerve length (rho = -0.8, p < 0.001), total nerve number (rho = -0.7, p < 0.001), number of main nerve trunks (rho = -0.6, p < 0.001), and number of nerve branches (rho = -0.7, p < 0.001) decreased significantly with increasing FECD stages. Comparing to the visual acuity, significant positive correlations were found for total nerve length (rho = 0.5, p = 0.012), total nerve number (rho = 0.5, p = 0.005), number of main nerve trunks (rho = 0.4, p = 0.017), and number of nerve branches (rho = 0.5, p = 0.009). With central corneal thickness, there were significant inverse correlations for total nerve length (rho = -0.6, p = 0.001), total nerve number (rho = -0.5, p = 0.012), number of main nerve trunks (rho = -0.4, p = 0.015), and number of nerve branches (rho = -0.4, p = 0.017). Central corneal sensation was full in all FECD stage 1, stage 2 and stage 3 eyes, but mildly reduced in FECD stage 4 eyes. Increasing severity of Fuchs' endothelial corneal dystrophy (FECD) is concurrent with marked attenuation of the density, as well as mild diminishment of the function, of the subbasal corneal nerve plexus in late stage of the disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bucher, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Adler, Werner UNSPECIFIED orcid.org/0000-0001-9791-5407 UNSPECIFIED Lehmann, Helmar C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hos, Deniz UNSPECIFIED UNSPECIFIED UNSPECIFIED Steven, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-435290
DOI:	10.1007/s00417-014-2678-3
Journal or Publication Title:	Graefes Arch. Clin. Exp. Ophthalmol.
Volume:	252
Number:	7
Page Range:	S. 1119 - 1127
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-702X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FLUORESCENCE MICROSCOPY; KERATOPLASTY; KERATITIS; TRANSPLANTATION; EXPRESSION; SURVIVAL; VIP Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43529