Pelzer, E. A., Hintzen, A., Timmermann, L. and Tittgemeyer, M. (2014). Satellite Systems of the Basal Ganglia - Anatomic Position, Clinical Relevance. Forschritte Neurol. Psychiatr., 82 (6). S. 323 - 330. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3522

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Abstract

The interaction of basal ganglia and other brain regions is more complex regarding anatomic and functional perspectives than previously assumed. Hence, the classical basal ganglia model has to be extended to at least four satellite systems modulating motor-executive, associative and limbic-motivational brain regions: (i) an indirect projection system, (ii) a striato-nigro-striatal loop, (iii) a hyperdirect projection system as well as additional projections to the subthalamic nucleus and (iv) multisynaptic connections from the cerebellum exerting influence on the indirect projection system. The investigation of these satellite systems would be invaluable to foster our understanding of basal ganglia circuitries and may yield a better appreciation of largely opaque symptoms like resting tremor in Parkinson's disease; analysis of these anatomic pathways and functional implications may facilitate explanatory model approaches to side effects due to dopaminergic therapy and deep brain stimulation in humans and thereby offer the possibility for new therapeutic approaches in movement disorders.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Pelzer, E. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hintzen, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tittgemeyer, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-436649
DOI: 10.1055/s-0034-1366372
Journal or Publication Title: Forschritte Neurol. Psychiatr.
Volume: 82
Number: 6
Page Range: S. 323 - 330
Date: 2014
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1439-3522
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MIDBRAIN SUPERIOR COLLICULUS; MEDIUM SPINY NEURONS; SUBTHALAMIC NUCLEUS; PARKINSONS-DISEASE; ORGANIZATION; DOPAMINE; STRIATUM; PATHWAYS; PROJECTIONS; CEREBELLUMMultiple languages
Clinical Neurology; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43664

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