Barbui, Tiziano, Thiele, Juergen, Carobbio, Alessandra ORCID: 0000-0001-9664-7084, Guglielmelli, Paola ORCID: 0000-0003-1809-284X, Rambaldi, Alessandro ORCID: 0000-0002-3739-7502, Vannucchi, Alessandro M. and Tefferi, Ayalew (2014). Discriminating between essential thrombocythemia and masked polycythemia vera in JAK2 mutated patients. Am. J. Hematol., 89 (6). S. 588 - 591. HOBOKEN: WILEY-BLACKWELL. ISSN 1096-8652

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Abstract

In patients not meeting the required hematocrit (HCT) or hemoglobin (Hb) thresholds according to BCSH and the WHO diagnostic criteria, the diagnosis of masked polycythemia vera (mPV) has been proposed. A comparison of HCT or Hb values with the expression of JAK2V617F, JAK2 exon 12, and CALR mutations in strictly WHO-defined 257 overt PV and 140 mPV (59 mPV according to BCSH) and 397 patients with essential thrombocythemia (ET) was performed. Hb and HCT thresholds of mPV patients were significantly higher than JAK2V617F ET (P<0.0001). The best cut-off for Hb to discriminate JAK2-mutated ET from PV was 16.5 g/dL for males and 16.0 g/dL for females. For HCT, this was 49% in males and 48% in females. The proportion of patients correctly classified as ET or PV when regarding Hb or HCT levels was 95% in males and 93% in females and 94% in both males and females, respectively. Am. J. Hematol. 89:588-590, 2014. (c) 2014 Wiley Periodicals, Inc.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Barbui, TizianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiele, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carobbio, AlessandraUNSPECIFIEDorcid.org/0000-0001-9664-7084UNSPECIFIED
Guglielmelli, PaolaUNSPECIFIEDorcid.org/0000-0003-1809-284XUNSPECIFIED
Rambaldi, AlessandroUNSPECIFIEDorcid.org/0000-0002-3739-7502UNSPECIFIED
Vannucchi, Alessandro M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tefferi, AyalewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-436999
DOI: 10.1002/ajh.23694
Journal or Publication Title: Am. J. Hematol.
Volume: 89
Number: 6
Page Range: S. 588 - 591
Date: 2014
Publisher: WILEY-BLACKWELL
Place of Publication: HOBOKEN
ISSN: 1096-8652
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MYELOPROLIFERATIVE NEOPLASMS; DIAGNOSIS; CLASSIFICATION; MUTATIONSMultiple languages
HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43699

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