Universität zu Köln

Kroeger, Nicolaus, Zabelina, Tatjana, Alchalby, Haefaa, Stuebig, Thomas, Wolschke, Christine, Ayuk, Francis, von Huenerbein, Natascha, Kvasnicka, Hans-Michael, Thiele, Juergen, Kreipe, Hans-Heinrich and Buesche, Guntram (2014). Dynamic of Bone Marrow Fibrosis Regression Predicts Survival after Allogeneic Stem Cell Transplantation for Myelofibrosis. Biol. Blood Marrow Transplant., 20 (6). S. 812 - 816. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1523-6536

Full text not available from this repository.

Abstract

We correlate regression of bone marrow fibrosis (BMF) on day 30 and 100 after dose- reduced allogeneic stem cell transplantation (allo-SCT) in 57 patients with primary or post-essential thrombocythemia/polycythemia vera myelofibrosis with graft function and survival. The distribution of International Prognostic Scoring System (IPSS) risk score categories was 1 patient with low risk, 5 patients with intermediate-1 risk, 18 patients with intermediate-2 risk, and 33 patients with high risk. Before allo-SCT, 41 patients (72%) were classified as XXX [myclofibrosis (MF)]-3 and 16 (28%) were classified as MF-2 according to the World Health Organization criteria. At postengraftment day +30 (+/- 10 days), 21% of the patients had near-complete or complete regression of BMF (MF-0/-1), and on day +100 ( 20 days), 54% were MF-0/-1. The 5-year overall survival rate at day +100 was 96% in patients with MF-0/-1 and 57% for those with MF-2/-3 (P = .04). There was no difference in BMF regression at day +100 between IPSS high-risk and low/intermediate-risk patients. Complete donor cell chimerism at day +100 was seen in 81% of patients with MF-0/-1 and in 31% of those with MF-2/-3. Patients with MF-2/-3 at day +100 were more likely to be transfusion-dependent for either RBCs (P = .014) or platelets (P = .018). Rapid BMF regression after reduced-intensity conditioning allo-SCT resulted in a favorable survival independent of IPSS risk score at transplantation. (C) 2014 American Society for Blood and Marrow Transplantation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kroeger, Nicolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Zabelina, Tatjana UNSPECIFIED UNSPECIFIED UNSPECIFIED Alchalby, Haefaa UNSPECIFIED UNSPECIFIED UNSPECIFIED Stuebig, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolschke, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Ayuk, Francis UNSPECIFIED UNSPECIFIED UNSPECIFIED von Huenerbein, Natascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Kvasnicka, Hans-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreipe, Hans-Heinrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Buesche, Guntram UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-437134
DOI:	10.1016/j.bbmt.2014.02.019
Journal or Publication Title:	Biol. Blood Marrow Transplant.
Volume:	20
Number:	6
Page Range:	S. 812 - 816
Date:	2014
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1523-6536
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERNATIONAL WORKING GROUP; IDIOPATHIC MYELOFIBROSIS; MYELOID METAPLASIA; PROGNOSTIC-FACTORS Multiple languages Hematology; Immunology; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43713