Universität zu Köln

Kraitsy, Klaus, Uecal, Muammer, Grossauer, Stefan, Bruckmann, Lukas, Pfleger, Florentina, Ropele, Stefan, Fazekas, Franz, Gruenbacher, Gerda, Patz, Silke, Absenger, Markus, Porubsky, Christian, Smolle-Juettner, Freyja, Tezer, Irem, Molcanyi, Marek, Fasching, Ulrike and Schaefer, Ute (2014). Repetitive Long-Term Hyperbaric Oxygen Treatment (HBOT) Administered after Experimental Traumatic Brain Injury in Rats Induces Significant Remyelination and a Recovery of Sensorimotor Function. PLoS One, 9 (5). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Cells in the central nervous system rely almost exclusively on aerobic metabolism. Oxygen deprivation, such as injury-associated ischemia, results in detrimental apoptotic and necrotic cell loss. There is evidence that repetitive hyperbaric oxygen therapy (HBOT) improves outcomes in traumatic brain-injured patients. However, there are no experimental studies investigating the mechanism of repetitive long-term HBOT treatment-associated protective effects. We have therefore analysed the effect of long-term repetitive HBOT treatment on brain trauma-associated cerebral modulations using the lateral fluid percussion model for rats. Trauma-associated neurological impairment regressed significantly in the group of HBO-treated animals within three weeks post trauma. Evaluation of somatosensory-evoked potentials indicated a possible remyelination of neurons in the injured hemisphere following HBOT. This presumption was confirmed by a pronounced increase in myelin basic protein isoforms, PLP expression as well as an increase in myelin following three weeks of repetitive HBO treatment. Our results indicate that protective long-term HBOT effects following brain injury is mediated by a pronounced remyelination in the ipsilateral injured cortex as substantiated by the associated recovery of sensorimotor function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kraitsy, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Uecal, Muammer UNSPECIFIED UNSPECIFIED UNSPECIFIED Grossauer, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruckmann, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfleger, Florentina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ropele, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Fazekas, Franz UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruenbacher, Gerda UNSPECIFIED UNSPECIFIED UNSPECIFIED Patz, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Absenger, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Porubsky, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Smolle-Juettner, Freyja UNSPECIFIED UNSPECIFIED UNSPECIFIED Tezer, Irem UNSPECIFIED UNSPECIFIED UNSPECIFIED Molcanyi, Marek UNSPECIFIED UNSPECIFIED UNSPECIFIED Fasching, Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-437850
DOI:	10.1371/journal.pone.0097750
Journal or Publication Title:	PLoS One
Volume:	9
Number:	5
Date:	2014
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MYELIN BASIC-PROTEIN; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; SOMATOSENSORY-EVOKED POTENTIALS; ISCHEMIA-REPERFUSION INJURY; FLUID-PERCUSSION INJURY; MITOCHONDRIAL-FUNCTION; CEREBRAL-ISCHEMIA; HEAD-INJURY; THERAPY; MODEL Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43785