Universität zu Köln

Cardenas-Morales, Lizbeth, Groen, Georg, Sim, Eun-Jin, Stingl, Julia C. ORCID: 0000-0002-1566-8156 and Kammer, Thomas ORCID: 0000-0002-2769-5645 (2014). Neural Activation in Humans during a Simple Motor Task Differs between BDNF Polymorphisms. PLoS One, 9 (5). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

The BDNF Val66Met polymorphism has been linked to decreased synaptic plasticity involved in motor learning tasks. We investigated whether individual differences in this polymorphism may promote differences in neural activity during a two-alternative forced-choice motor performance. In two separate sessions, the BOLD signal from 22 right-handed healthy men was measured during button presses with the left and right index finger upon visual presentation of an arrow. 11 men were Val66Val carriers (ValVal group), the other 11 men carried either the Val66Met or the Met66Met polymorphism (Non-ValVal group). Reaction times, resting and active motor thresholds did not differ between ValVal and Non-ValVal groups. Compared to the ValVal group the Non-ValVal group showed significantly higher BOLD signals in the right SMA and motor cingulate cortex during motor performance. This difference was highly consistent for both hands and across all four sessions. Our finding suggests that this BDNF polymorphism may not only influence complex performance during motor learning but is already associated with activation differences during rather simple motor tasks. The higher BOLD signal observed in Non-ValVal subjects suggests the presence of cumulative effects of the polymorphism on the motor system, and may reflect compensatory functional activation mediating equal behavioral performance between groups.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cardenas-Morales, Lizbeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Groen, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Sim, Eun-Jin UNSPECIFIED UNSPECIFIED UNSPECIFIED Stingl, Julia C. UNSPECIFIED orcid.org/0000-0002-1566-8156 UNSPECIFIED Kammer, Thomas UNSPECIFIED orcid.org/0000-0002-2769-5645 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-438320
DOI:	10.1371/journal.pone.0096722
Journal or Publication Title:	PLoS One
Volume:	9
Number:	5
Date:	2014
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FACTOR VAL66MET POLYMORPHISM; NEUROTROPHIC FACTOR; CORTICAL EXCITABILITY; FINGER MOVEMENTS; HUMAN-MEMORY; PLASTICITY; BRAIN; CORTEX; HANDEDNESS; STIMULATION Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43832