Universität zu Köln

Nettekoven, Charlotte ORCID: 0000-0002-8944-4681, Volz, Lukas J. ORCID: 0000-0002-0161-654X, Kutscha, Martha, Pool, Eva-Maria ORCID: 0000-0001-8007-9588, Rehme, Anne K., Eickhoff, Simon B. ORCID: 0000-0001-6363-2759, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Grefkes, Christian ORCID: 0000-0002-1656-720X (2014). Dose-Dependent Effects of Theta Burst rTMS on Cortical Excitability and Resting-State Connectivity of the Human Motor System. J. Neurosci., 34 (20). S. 6849 - 6860. WASHINGTON: SOC NEUROSCIENCE. ISSN 1529-2401

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Abstract

Theta burst stimulation (TBS), a specific protocol of repetitive transcranial magnetic stimulation (rTMS), induces changes in cortical excitability that last beyond stimulation. TBS-induced aftereffects, however, vary between subjects, and the mechanisms underlying these aftereffects to date remain poorly understood. Therefore, the purpose of this study was to investigate whether increasing the number of pulses of intermittent TBS (iTBS) (1) increases cortical excitability as measured by motor-evoked potentials (MEPs) and (2) alters functional connectivity measured using resting-state fMRI, in a dose-dependent manner. Sixteen healthy, human subjects received three serially applied iTBS blocks of 600 pulses over the primary motor cortex (M1 stimulation) and the parieto-occipital vertex (sham stimulation) to test for dose-dependent iTBS effects on cortical excitability and functional connectivity (four sessions in total). iTBS over M1 increased MEP amplitudes compared with sham stimulation after each stimulation block. Although the increase in MEP amplitudes did not differ between the first and second block of M1 stimulation, we observed a significant increase after three blocks (1800 pulses). Furthermore, iTBS enhanced resting-state functional connectivity between the stimulated M1 and premotor regions in both hemispheres. Functional connectivity between M1 and ipsilateral dorsal premotor cortex further increased dose-dependently after 1800 pulses of iTBS over M1. However, no correlation between changes in MEP amplitudes and functional connectivity was detected. In summary, our data show that increasing the number of iTBS stimulation blocks results in dose-dependent effects at the local level (cortical excitability) as well as at a systems level (functional connectivity) with a dose-dependent enhancement of dorsal premotor cortex-M1 connectivity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nettekoven, Charlotte UNSPECIFIED orcid.org/0000-0002-8944-4681 UNSPECIFIED Volz, Lukas J. UNSPECIFIED orcid.org/0000-0002-0161-654X UNSPECIFIED Kutscha, Martha UNSPECIFIED UNSPECIFIED UNSPECIFIED Pool, Eva-Maria UNSPECIFIED orcid.org/0000-0001-8007-9588 UNSPECIFIED Rehme, Anne K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-438341
DOI:	10.1523/JNEUROSCI.4993-13.2014
Journal or Publication Title:	J. Neurosci.
Volume:	34
Number:	20
Page Range:	S. 6849 - 6860
Date:	2014
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	1529-2401
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; FUNCTIONAL CONNECTIVITY; REPETITIVE TMS; PHYSIOLOGICAL-BASIS; CORTEX; INHIBITION; PLASTICITY; COMMUNICATION; MODULATION; NETWORKS Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43834