Larenas-Linnemann, Desiree, Michels, Alexandra, Dinger, Hanna, Arias-Cruz, Alfredo ORCID: 0000-0002-4077-4225, Ambriz Moreno, Marichuy, Bedolla Barajas, Martin, Cerino Javier, Ruth, de la Luz Cid del Prado, Maria, Cruz Moreno, Manuel Alejandro, Diego Vergara, Laura, Garcia Almaraz, Roberto, Garcia-Cobas, Cecilia Y., Garcia Imperial, Daniel Alberto, Garcia Munoz, Rosa, Hernandez Colin, Dante, Linares Zapien, Francisco Javier, Luna Pech, Jorge Agustin, Matta Campos, Juan Jose, Martinez Jimenez, Norma, Medina Avalos, Miguel, Medina Hernandez, Alejandra, Monteverde Maldonado, Albero, Nereida Lopez, Doris, Pizano Nazara, Luis Julian, Ramirez Sanchez, Emanuel, Ramos Lopez, Jose Domingo, Rodriguez-Perez, Noel, Rodriguez Ortiz, Pablo G., Shah-Hosseini, Kijawasch and Moesges, Ralph (2014). In the (sub)tropics Allergic Rhinitis and Its Impact on Asthma classification of allergic rhinitis is more useful than perennial-seasonal classification. Am. J. Rhinol. Allergy, 28 (3). S. 232 - 239. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1945-8932

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Abstract

Background: Two different allergic rhinitis (AR) symptom phenotype classifications exist. Treatment recommendations are based on intermittent-persistent (INT-PER) cataloging, but clinical trials still use the former seasonal AR-perennial AR (SAR-PAR) classification. This study was designed to describe how INT-PER, mild-moderate/severe and SAR-PAR of patients seen by allergists are distributed over the different climate zones in a (sub) tropical country and how these phenotypes relate to allergen sensitization patterns. Methods: Six climate zones throughout Mexico were determined, based on National Geographic Institute (Instituto Nacional de Estadistica y Geografia) data. Subsequent AR patients (2-68 years old) underwent a blinded, standardized skin-prick test and filled out a validated questionnaire phenotyping AR. Results: Five hundred twenty-nine subjects participated in this study. In the tropical zone with 87% house-dust mite sensitization, INT (80.9%; p < 0.001) and PAR (91%; p = 0.04) were more frequent than in the subtropics. In the central high-pollen areas, there was less moderate/severe AR (65.5%; p < 0.005). Frequency of comorbid asthma showed a clear north-south gradient, from 25% in the dry north to 59% in the tropics (p < 0.005). No differences exist in AR cataloging among patients with different sensitization patterns, with two minor exceptions (more PER in tree sensitized and more PAR in mold positives; p < 0.05). Conclusion: In a (sub) tropical country the SAR-PAR classification seems of limited value and bears poor relation with the INT-PER classification. INT is more frequent in the tropical zone. Because PER has been shown to relate to AR severity, clinical trials should select patients based on INT-PER combined with the severity cataloging because these make for a better treatment guide than SAR-PAR.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Larenas-Linnemann, DesireeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michels, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dinger, HannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arias-Cruz, AlfredoUNSPECIFIEDorcid.org/0000-0002-4077-4225UNSPECIFIED
Ambriz Moreno, MarichuyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bedolla Barajas, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cerino Javier, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de la Luz Cid del Prado, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cruz Moreno, Manuel AlejandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diego Vergara, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia Almaraz, RobertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Cobas, Cecilia Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia Imperial, Daniel AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia Munoz, RosaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hernandez Colin, DanteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linares Zapien, Francisco JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luna Pech, Jorge AgustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matta Campos, Juan JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinez Jimenez, NormaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Medina Avalos, MiguelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Medina Hernandez, AlejandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monteverde Maldonado, AlberoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nereida Lopez, DorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pizano Nazara, Luis JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez Sanchez, EmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramos Lopez, Jose DomingoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez-Perez, NoelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez Ortiz, Pablo G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shah-Hosseini, KijawaschUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moesges, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-438759
DOI: 10.2500/ajra.2014.28.4035
Journal or Publication Title: Am. J. Rhinol. Allergy
Volume: 28
Number: 3
Page Range: S. 232 - 239
Date: 2014
Publisher: SAGE PUBLICATIONS INC
Place of Publication: THOUSAND OAKS
ISSN: 1945-8932
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CHILDHOOD ISAAC PHASE-3; ARIA GUIDELINES; PREVALENCE; SYMPTOMS; POPULATION; SEVERITY; VALIDATION; NATIONWIDE; DIAGNOSIS; CHILDRENMultiple languages
OtorhinolaryngologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43875

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