Geyer, Hans, Schaenzer, Wilhelm and Thevis, Mario (2014). Anabolic agents: recent strategies for their detection and protection from inadvertent doping. Br. J. Sports Med., 48 (10). S. 820 - 828. LONDON: BMJ PUBLISHING GROUP. ISSN 1473-0480

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Abstract

According to the World Anti-Doping Agency (WADA) Prohibited List, anabolic agents consist of exogenous anabolic androgenic steroids (AAS), endogenous AAS and other anabolic agents such as clenbuterol and selective androgen receptor modulators (SARMs). Currently employed strategies for their improved detection include the prolongation of the detection windows for exogenous AAS, non-targeted and indirect analytical approaches for the detection of modified steroids (designer steroids), the athlete's biological passport and isotope ratio mass spectrometry for the detection of the misuse of endogenous AAS, as well as preventive doping research for the detection of SARMs. The recent use of these strategies led to 4-80-fold increases of adverse analytical findings for exogenous AAS, to the detection of the misuse of new designer steroids, to adverse analytical findings of different endogenous AAS and to the first adverse analytical findings of SARMs. The strategies of the antidoping research are not only focused on the development of methods to catch the cheating athlete but also to protect the clean athlete from inadvertent doping. Within the past few years several sources of inadvertent doping with anabolic agents have been identified. Among these are nutritional supplements adulterated with AAS, meat products contaminated with clenbuterol, mycotoxin (zearalenone) contamination leading to zeranol findings, and natural products containing endogenous AAS. The protection strategy consists of further investigations in case of reasonable suspicion of inadvertent doping, publication of the results, education of athletes and development of methods to differentiate between intentional and unintentional doping.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Geyer, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaenzer, WilhelmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thevis, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-439102
DOI: 10.1136/bjsports-2014-093526
Journal or Publication Title: Br. J. Sports Med.
Volume: 48
Number: 10
Page Range: S. 820 - 828
Date: 2014
Publisher: BMJ PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1473-0480
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANDROGEN RECEPTOR MODULATORS; MASS-SPECTROMETRIC CHARACTERIZATION; SUPPLEMENTS DIETARY-SUPPLEMENTS; SPORTS NUTRITION FOODS; HUMAN URINE; LIQUID-CHROMATOGRAPHY; ENDOGENOUS STEROIDS; REFERENCE RANGES; ERGOGENIC AIDS; S-4 ANDARINEMultiple languages
Sport SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43910

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