Universität zu Köln

Ringe, J. D. and Farahmand, P. (2014). Improved real-life adherence of 6-monthly denosumab injections due to positive feedback based on rapid 6-month BMD increase and good safety profile. Rheumatol. Int., 34 (5). S. 727 - 733. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1437-160X

Full text not available from this repository.

Abstract

Almost 50 % of osteoporosis (OP) patients discontinue bisphosphonate (BP) therapy within 1-2 years after the start of their treatment. Denosumab's longer dosing interval with its administration every 6 months (Q6M) as a subcutaneous (sc) injection might result in a better real-life treatment adherence and persistence than weekly or monthly oral BP treatment regimen. The objectives of this open, investigator-initiated, prospective, observational, single-center study were to evaluate adherence with denosumab 60 mg sc every 6 months (Q6M) (Prolia(A (R))) injections in osteoporotic patients in a routine clinical care setting and to describe whether positive feedback to OP patients based on measured bone mineral density (BMD) increases and good safety profile have an impact on patients' real-life adherence. Results indicate that the rarity of adverse events and reduced dosage frequency together with the consistency of rapid and highly significant increases in BMD already after 6 months of denosumab therapy used as a positive reinforcement during doctor-patient interactions had a significant, positive impact on osteoporotic patient's adherence to continue with the 6-monthly sc denosumab injections.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ringe, J. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Farahmand, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-439409
DOI:	10.1007/s00296-012-2663-2
Journal or Publication Title:	Rheumatol. Int.
Volume:	34
Number:	5
Page Range:	S. 727 - 733
Date:	2014
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1437-160X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSTMENOPAUSAL WOMEN; OSTEOPOROSIS; THERAPY; CONSEQUENCES; FRACTURES; BENEFIT; CARE Multiple languages Rheumatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43940