Universität zu Köln

Venkataraman, Girish, Mirza, M. Kamran, Eichenauer, Dennis A. and Diehl, Volker (2014). Current status of prognostication in classical Hodgkin lymphoma. Br. J. Haematol., 165 (3). S. 287 - 300. HOBOKEN: WILEY. ISSN 1365-2141

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Abstract

Classical Hodgkin lymphoma (cHL) is characterized by a paucity of neoplastic Hodgkin/Reed Sternberg (HRS) cells within a complex cellular milieu that is rendered immunologically incapable of reacting against CD30(+)HRS cells due to a plethora of immune escape mechanisms initiated by the neoplastic cells. Accounting for 25% of all lymphomas and nearly 95% of all Hodgkin lymphomas, patients with cHL are typically young adults. Besides traditional prognostic factors, such as the International Prognostic Index (IPI), newer imaging and ancillary biomarkers (CD68, Galectin-1 and plasma microRNA) have shown promise. Furthermore, the evolution of gene expression profiling (GEP) in recent years has enabled the development of several practically feasible GEP-based predictors with prognostic relevance. This review discusses the current status of clinical prognostication in cHL, the critical role of histological evaluation in light of several mimicking entities, and the relevance of tissue as well as serum biomarkers pertaining to immune escape mechanisms and recent GEP studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Venkataraman, Girish UNSPECIFIED UNSPECIFIED UNSPECIFIED Mirza, M. Kamran UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichenauer, Dennis A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Diehl, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-439613
DOI:	10.1111/bjh.12759
Journal or Publication Title:	Br. J. Haematol.
Volume:	165
Number:	3
Page Range:	S. 287 - 300
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-2141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REED-STERNBERG CELLS; TUMOR-ASSOCIATED MACROPHAGES; REGULATORY T-CELLS; HIGH-DOSE CHEMORADIOTHERAPY; LATENT MEMBRANE-PROTEIN; GENE-EXPRESSION; MICRODISSECTED HODGKIN; CD20 EXPRESSION; EBV INFECTION; FREE SURVIVAL Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43961