Mueller, Nike, Schulte, Dominik M., Hillebrand, Susann, Tuerk, Kathrin, Hampe, Jochen ORCID: 0000-0002-2421-6127, Schafmayer, Clemens, Brosch, Mario ORCID: 0000-0001-8983-6557, von Schoenfels, Witigo, Ahrens, Markus, Zeuner, Rainald, Schroeder, Johann O., Blueher, Matthias, Gutschow, Christian, Freitag-Wolf, Sandra, Stelmach-Mardas, Marta, Saggau, Carina, Schreiber, Stefan and Laudes, Matthias (2014). B Lymphocyte Stimulator (BLyS) Is Expressed in Human Adipocytes In Vivo and Is Related to Obesity but Not to Insulin Resistance. PLoS One, 9 (4). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Inflammation and metabolism have been shown to be evolutionary linked and increasing evidence exists that pro-inflammatory factors are involved in the pathogenesis of obesity and type 2 diabetes. Until now, most data suggest that within adipose tissue these factors are secreted by cells of the innate immune system, e. g. macrophages. In the present study we demonstrate that B lymphocyte stimulator (BLyS) is increased in human obesity. In contrast to several pro-inflammatory factors, we found the source of BLyS in human adipose tissue to be the adipocytes rather than immune cells. In grade 3 obese human subjects, expression of BLyS in vivo in adipose tissue is significantly increased (p<0.001). Furthermore, BLyS serum levels are elevated in grade 3 human obesity (862.5+222.0 pg/ml vs. 543.7+60.7 pg/ml in lean controls, p<0.001) and are positively correlated to the BMI (r = 0.43, p<0.0002). In the present study, bariatric surgery significantly altered serum BLyS concentrations. In contrast, weight loss due to a very-low-calorie-formula-diet (800 kcal/d) had no such effect. To examine metabolic activity of BLyS, in a translational research approach, insulin sensitivity was measured in human subjects in vivo before and after treatment with the human recombinant anti-BLyS antibody belimumab. Since BLyS is known to promote B-cell proliferation and immunoglobulin secretion, the present data suggest that adipocytes of grade 3 obese human subjects are able to activate the adaptive immune system, suggesting that in metabolic inflammation in humans both, innate and adaptive immunity, are of pathophysiological relevance.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mueller, NikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulte, Dominik M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hillebrand, SusannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tuerk, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hampe, JochenUNSPECIFIEDorcid.org/0000-0002-2421-6127UNSPECIFIED
Schafmayer, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brosch, MarioUNSPECIFIEDorcid.org/0000-0001-8983-6557UNSPECIFIED
von Schoenfels, WitigoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahrens, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeuner, RainaldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeder, Johann O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blueher, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gutschow, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Freitag-Wolf, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stelmach-Mardas, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saggau, CarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schreiber, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laudes, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-440724
DOI: 10.1371/journal.pone.0094282
Journal or Publication Title: PLoS One
Volume: 9
Number: 4
Date: 2014
Publisher: PUBLIC LIBRARY SCIENCE
Place of Publication: SAN FRANCISCO
ISSN: 1932-6203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NECROSIS-FACTOR FAMILY; ADIPOSE-TISSUE; METABOLIC SYNDROME; CELLS; BAFF; ASSOCIATION; MECHANISMS; OVERWEIGHT; IMPACT; WNT-5AMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/44072

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