Universität zu Köln

Gaspar, John Antonydas, Doss, Michael Xavier, Hengstler, Jan Georg, Cadenas, Cristina, Hescheler, Juergen and Sachinidis, Agapios (2014). Unique Metabolic Features of Stem Cells, Cardiomyocytes, and Their Progenitors. Circ.Res., 114 (8). S. 1346 - 1361. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1524-4571

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Abstract

Recently, growing attention has been directed toward stem cell metabolism, with the key observation that the plasticity of stem cells also reflects the plasticity of their energy substrate metabolism. There seems to be a clear link between the self-renewal state of stem cells, in which cells proliferate without differentiation, and the activity of specific metabolic pathways. Differentiation is accompanied by a shift from anaerobic glycolysis to mitochondrial respiration. This metabolic switch of differentiating stem cells is required to cover the energy demands of the different organ-specific cell types. Among other metabolic signatures, amino acid and carbohydrate metabolism is most prominent in undifferentiated embryonic stem cells, whereas the fatty acid metabolic signature is unique in cardiomyocytes derived from embryonic stem cells. Identifying the specific metabolic pathways involved in pluripotency and differentiation is critical for further progress in the field of developmental biology and regenerative medicine. The recently generated knowledge on metabolic key processes may help to generate mature stem cell-derived somatic cells for therapeutic applications without the requirement of genetic manipulation. In the present review, the literature about metabolic features of stem cells and their cardiovascular cell derivatives as well as the specific metabolic gene signatures differentiating between stem and differentiated cells are summarized and discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gaspar, John Antonydas UNSPECIFIED UNSPECIFIED UNSPECIFIED Doss, Michael Xavier UNSPECIFIED UNSPECIFIED UNSPECIFIED Hengstler, Jan Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Cadenas, Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hescheler, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Sachinidis, Agapios UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-440740
DOI:	10.1161/CIRCRESAHA.113.302021
Journal or Publication Title:	Circ.Res.
Volume:	114
Number:	8
Page Range:	S. 1346 - 1361
Date:	2014
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1524-4571
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PENTOSE-PHOSPHATE PATHWAY; O-GLCNAC LEVELS; FUNCTIONAL-CHARACTERIZATION; MITOCHONDRIAL BIOGENESIS; CHROMOSOMAL LOCALIZATION; HEXOSAMINE BIOSYNTHESIS; TRANSCRIPTOME ANALYSIS; BETA-HYDROXYBUTYRATE; RAT-HEART; PLURIPOTENT Multiple languages Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44074