Universität zu Köln

Xhaard, A., Rzepecki, P., Valcarcel, D., Santarone, S., Fuerst, S., Serrano, D., De Angelis, G., Krueger, W. and Scheid, C. (2014). Optimization of health-care organization and perceived improvement of patient comfort by switching from intra-venous BU four-times-daily infusions to a once-daily administration scheme in adult hematopoietic stem cell recipients. Bone Marrow Transplant., 49 (4). S. 509 - 513. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5365

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Abstract

Previous studies have shown an equivalent pharmacokinetic profile between four-times-daily (4QD) and once-daily (QD) administration of intra-venous (IV) BU, without increased toxicity. We assess the impact of a switch in IV BU from a 4QD to a QD schedule, in terms of health-care organization, staff working conditions, quality of care dispensed and perceived patient comfort. Clinicians, nurses and pharmacists from nine allogeneic transplantation units in five European countries were interviewed face to face. Overall perception of QD versus 4QD BU was very positive. Both administration schemes were evaluated to be equally efficaciousZ. QD BU was perceived to be safer and more convenient. Clinicians and nurses perceived that patient comfort was improved, due to fewer complications associated with repeated infusions, and avoiding night infusions associated with stress, anxiety and decreased quality of sleep. Switching from 4QD to QD BU had a significant impact on health-care organization, with a better integration in the overall management and usual timelines in the pharmacies and transplantation units. Time spent to prepare and administer BU was significantly reduced, leading to potential financial savings that merit further assessment and would be of particular interest in the current economic climate.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Xhaard, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rzepecki, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Valcarcel, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Santarone, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuerst, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Serrano, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED De Angelis, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krueger, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-441494
DOI:	10.1038/bmt.2013.220
Journal or Publication Title:	Bone Marrow Transplant.
Volume:	49
Number:	4
Page Range:	S. 509 - 513
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DAILY INTRAVENOUS BUSULFAN; VENOOCCLUSIVE DISEASE; ORAL BUSULFAN; TRANSPLANTATION; PHARMACOKINETICS; FLUDARABINE; REGIMEN; PART; AML Multiple languages Biophysics; Oncology; Hematology; Immunology; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44149