Wedemeyer, I., Kreppel, M., Scheer, M., Zoeller, J. E., Buettner, R. and Drebber, U. (2014). Histopathological assessment of tumour regression, nodal stage and status of resection margins determines prognosis in patients with oral squamous cell carcinoma treated with neoadjuvant radiochemotherapy. Oral Dis., 20 (3). S. e81 - 9. HOBOKEN: WILEY. ISSN 1601-0825

Full text not available from this repository.

Abstract

Objectives In advanced oral squamous cell carcinoma (OSCC), tumour regression after neoadjuvant radiochemotherapy seems to be an important prognostic factor. In this study, we intended to compare regression grading according to two previously described regression models and to analyse the association of tumour regression and other tumour characteristics with patients' characteristics and overall survival. Methods The retrospective study included 63 treatment-naive patients with primary OSCC of stages II-IV, who were treated with a concomitant neoadjuvant radiochemotherapy followed by radical surgery. Assessment of histopathological features was performed, there under regression grading according to two previously described regression models. Results Both tumour regression models provided comparable results in terms of distribution of different regression grades. In univariate analysis regression gradings (P=0.003 and P=0.007), ypT-stage, ypN-stage and status of resection margins (P<0.001) were significantly associated with the 5-year overall survival (OS). None of the pretreatment clinicopathological parameters showed association with histopathological tumour regression. Multivariate analysis revealed the status of resection margins and of lymph node metastasis as statistically significant features for OS (P=0.020 and P=0.003, respectively). Conclusion Tumour regression grading, nodal stage and status of resection margins predict prognosis in patients after neoadjuvant treatment. Currently, there are no pretreatment clinicopathological parameters, which predicting good tumour response to therapy. Thus, identifying non-responding patients, which might benefit from an intensified systemic therapy, requires surgical resection and consecutive histopathological assessment. Therefore, further investigation and validation of new, especially, molecular predictors of tumour response to radiochemotherapy remains an unmet, future clinical need.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wedemeyer, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreppel, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheer, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zoeller, J. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buettner, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drebber, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-441914
DOI: 10.1111/odi.12137
Journal or Publication Title: Oral Dis.
Volume: 20
Number: 3
Page Range: S. e81 - 9
Date: 2014
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1601-0825
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OROPHARYNGEAL CANCER; INDUCTION CHEMOTHERAPY; LUNG-CANCER; PHASE-II; NECK; HEAD; SURGERY; EXPRESSION; CISPLATIN; SURVIVALMultiple languages
Dentistry, Oral Surgery & MedicineMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/44191

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item