Universität zu Köln

Picco, Agnese, Polidori, M. Cristina, Ferrara, Michela, Cecchetti, Roberta, Arnaldi, Dario ORCID: 0000-0001-6823-6069, Baglioni, Mauro, Morbelli, Silvia ORCID: 0000-0002-7833-6095, Bastiani, Patrizia, Bossert, Irene ORCID: 0000-0003-0938-3418, Fiorucci, Giuliana, Brugnolo, Andrea ORCID: 0000-0002-5708-0940, Dottorini, Massimo Eugenio, Nobili, Flavio ORCID: 0000-0001-9811-0897 and Mecocci, Patrizia ORCID: 0000-0003-0729-5246 (2014). Plasma antioxidants and brain glucose metabolism in elderly subjects with cognitive complaints. Eur. J. Nucl. Med. Mol. Imaging, 41 (4). S. 764 - 776. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Purpose The role of oxidative stress is increasingly recognized in cognitive disorders of the elderly, notably Alzheimer's disease (AD). In these subjects brain(18)F-FDG PET is regarded as a reliable biomarker of neurodegeneration. We hypothesized that oxidative stress could play a role in impairing brain glucose utilization in elderly subjects with increasing severity of cognitive disturbance. Methods The study group comprised 85 subjects with cognitive disturbance of increasing degrees of severity including 23 subjects with subjective cognitive impairment (SCI), 28 patients with mild cognitive impairment and 34 patients with mild AD. In all subjects brain FDG PET was performed and plasma activities of extracellular superoxide dismutase (eSOD), catalase and glutathione peroxidase were measured. Voxel-based analysis (SPM8) was used to compare FDG PET between groups and to evaluate correlations between plasma antioxidants and glucose metabolism in the whole group of subjects, correcting for age and Mini-Mental State Examination score. Results Brain glucose metabolism progressively decreased in the bilateral posterior temporoparietal and cingulate cortices across the three groups, from SCI to mild AD. eSOD activity was positively correlated with glucose metabolism in a large area of the left temporal lobe including the superior, middle and inferior temporal gyri and the fusiform gyrus. Conclusion These results suggest a role of oxidative stress in the impairment of glucose utilization in the left temporal lobe structures in elderly patients with cognitive abnormalities, including AD and conditions predisposing to AD. Further studies exploring the oxidative stress-energy metabolism axis are considered worthwhile in larger groups of these patients in order to identify pivotal pathophysiological mechanisms and innovative therapeutic opportunities.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Picco, Agnese UNSPECIFIED UNSPECIFIED UNSPECIFIED Polidori, M. Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferrara, Michela UNSPECIFIED UNSPECIFIED UNSPECIFIED Cecchetti, Roberta UNSPECIFIED UNSPECIFIED UNSPECIFIED Arnaldi, Dario UNSPECIFIED orcid.org/0000-0001-6823-6069 UNSPECIFIED Baglioni, Mauro UNSPECIFIED UNSPECIFIED UNSPECIFIED Morbelli, Silvia UNSPECIFIED orcid.org/0000-0002-7833-6095 UNSPECIFIED Bastiani, Patrizia UNSPECIFIED UNSPECIFIED UNSPECIFIED Bossert, Irene UNSPECIFIED orcid.org/0000-0003-0938-3418 UNSPECIFIED Fiorucci, Giuliana UNSPECIFIED UNSPECIFIED UNSPECIFIED Brugnolo, Andrea UNSPECIFIED orcid.org/0000-0002-5708-0940 UNSPECIFIED Dottorini, Massimo Eugenio UNSPECIFIED UNSPECIFIED UNSPECIFIED Nobili, Flavio UNSPECIFIED orcid.org/0000-0001-9811-0897 UNSPECIFIED Mecocci, Patrizia UNSPECIFIED orcid.org/0000-0003-0729-5246 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-442177
DOI:	10.1007/s00259-013-2638-x
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	41
Number:	4
Page Range:	S. 764 - 776
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTRACELLULAR-SUPEROXIDE DISMUTASE; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; TAU PHOSPHORYLATION; IMPAIRMENT; MITOCHONDRIA; PATHOLOGY; INCREASE; FEEDBACK; CORTEX Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44217