Universität zu Köln

Boller, Jana K., Barbe, Michael T., Pauls, K. Amande M., Reck, Christiane, Brand, Matthias, Maier, Franziska, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Timmermann, Lars and Kalbe, Elke (2014). Decision-making under risk is improved by both dopaminergic medication and subthalamic stimulation in Parkinson's disease. Exp. Neurol., 254. S. 70 - 78. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2430

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Abstract

Inconsistent findings regarding the effects of dopaminergic medication (MED) and deep brain stimulation (DES) of the subthalamic nucleus (STN) on decision making processes and impulsivity in Parkinson's disease (PD) patients have been reported. This study investigated the influence of MED and STN-DBS on decision-making under risk. Eighteen non-demented PD patients, treated with both MED and STN-DBS (64.3 +/- 10.2 years, UPDRS III MED off, DBS off 45.5 +/- 17.1) were tested with the Game of Dice Task (GDT) which probes decision-making under risk during four conditions: MED on/DBS on, MED on/DBS off, MED off/DBS on, and MED off/DBS off. Task performance across conditions was compared analyzing two GDT-parameters: (i) the net score indicating advantageous decisions, and (ii) the patient's ability to use negative feedback. Significantly higher GDT net scores were observed in Med on in contrast to Med off conditions as well as in DBS on versus DBS off conditions. However, no effect of therapy for the patient's ability to make use of negative feedback could be detected. The data suggest a positive influence of both MED and STN-DBS on making decisions under risk in PD patients, an effect which seems to be mediated by mechanisms other than the use of negative feedback. (C) 2014 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Boller, Jana K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauls, K. Amande M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reck, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Brand, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-442225
DOI:	10.1016/j.expneurol.2014.01.005
Journal or Publication Title:	Exp. Neurol.
Volume:	254
Page Range:	S. 70 - 78
Date:	2014
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1090-2430
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; NUCLEUS STIMULATION; EXECUTIVE FUNCTIONS; COGNITIVE FUNCTION; NEUROPSYCHOLOGICAL CHANGES; FEEDBACK; LEVODOPA; DEFICITS; PROBABILITIES; IMPULSIVITY Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44222