Universität zu Köln

Damm, Michael, Pikart, Louisa K., Reimann, Heike, Burkert, Silke, Goektas, Oender, Haxel, Boris, Frey, Sabine, Charalampakis, Ioannis, Beule, Achim ORCID: 0000-0002-1622-6077, Renner, Berthold, Hummel, Thomas and Huettenbrink, Karl-Bernd (2014). Olfactory training is helpful in postinfectious olfactory loss: A randomized, controlled, multicenter study. Laryngoscope, 124 (4). S. 826 - 832. HOBOKEN: WILEY. ISSN 1531-4995

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Abstract

Objectives/Hypothesis The aim of this study was to evaluate the effects of olfactory training (OT) on olfactory function in patients with persistent postinfectious olfactory dysfunction (PIOD). Study Design Randomized, single-blind, controlled, multicenter crossover study. Methods Twelve tertiary university medical centers participated. Investigations were performed at three visits (baseline, after 18 weeks, and after 36 weeks), including only subjects with PIOD of <24-months duration. At each visit, participants received detailed assessment of olfactory function. Seventy subjects trained with high concentrations of four odors for 18 weeks; the other half (n = 74) trained with low concentrations of odors. For the following 18 weeks this regimen was switched. Results After 18 weeks, olfactory function improved in the high-training group in 18 of 70 participants (26%), whereas only 11/74 improved in the low-training group (15%). In subjects with a duration of olfactory dysfunction of <12 months, olfactory function improved in 15/24 participants (63%) of the high-training group and in 6/31 participants (19%) of the low-training group (P = .03). Conclusions OT improves PIOD, and the use of odors at higher concentrations is beneficial to improvement. OT is a safe procedure and appears to be particularly useful in patients who start OT within 12 months after the onset of the disorder. OT is the first successful therapy regime in patients with PIOD. Level of Evidence 1b. Laryngoscope, 124:826-831, 2014

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Damm, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Pikart, Louisa K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reimann, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Burkert, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Goektas, Oender UNSPECIFIED UNSPECIFIED UNSPECIFIED Haxel, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Frey, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Charalampakis, Ioannis UNSPECIFIED UNSPECIFIED UNSPECIFIED Beule, Achim UNSPECIFIED orcid.org/0000-0002-1622-6077 UNSPECIFIED Renner, Berthold UNSPECIFIED UNSPECIFIED UNSPECIFIED Hummel, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Huettenbrink, Karl-Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-442758
DOI:	10.1002/lary.24340
Journal or Publication Title:	Laryngoscope
Volume:	124
Number:	4
Page Range:	S. 826 - 832
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-4995
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UPPER RESPIRATORY-TRACT; DYSFUNCTION; SMELL; SENSITIVITY; INFECTION; DISORDERS Multiple languages Medicine, Research & Experimental; Otorhinolaryngology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44275