Kevei, Eva ORCID: 0000-0002-0560-9208 and Hoppe, Thorsten
ORCID: 0000-0002-4734-9352
(2014).
Ubiquitin sets the timer: impacts on aging and longevity.
Nat. Struct. Mol. Biol., 21 (4).
S. 290 - 293.
NEW YORK:
NATURE PUBLISHING GROUP.
ISSN 1545-9985
Abstract
Protein homeostasis is essential for cellular function, organismal growth and viability. Damaged and aggregated proteins are turned over by two major proteolytic routes of the cellular quality-control pathways: the ubiquitin-proteasome system and autophagy. For both these pathways, ubiquitination provides the recognition signal for substrate selection. This Commentary discusses how ubiquitin-dependent proteolytic pathways are coordinated with stress-and aging-induced signals.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-442776 | ||||||||||||
DOI: | 10.1038/nsmb.2806 | ||||||||||||
Journal or Publication Title: | Nat. Struct. Mol. Biol. | ||||||||||||
Volume: | 21 | ||||||||||||
Number: | 4 | ||||||||||||
Page Range: | S. 290 - 293 | ||||||||||||
Date: | 2014 | ||||||||||||
Publisher: | NATURE PUBLISHING GROUP | ||||||||||||
Place of Publication: | NEW YORK | ||||||||||||
ISSN: | 1545-9985 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Faculty of Mathematics and Natural Sciences | ||||||||||||
Divisions: | Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics | ||||||||||||
Subjects: | no entry | ||||||||||||
Uncontrolled Keywords: |
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/44277 |
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