Universität zu Köln

Kevei, Eva ORCID: 0000-0002-0560-9208 and Hoppe, Thorsten ORCID: 0000-0002-4734-9352 (2014). Ubiquitin sets the timer: impacts on aging and longevity. Nat. Struct. Mol. Biol., 21 (4). S. 290 - 293. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1545-9985

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Abstract

Protein homeostasis is essential for cellular function, organismal growth and viability. Damaged and aggregated proteins are turned over by two major proteolytic routes of the cellular quality-control pathways: the ubiquitin-proteasome system and autophagy. For both these pathways, ubiquitination provides the recognition signal for substrate selection. This Commentary discusses how ubiquitin-dependent proteolytic pathways are coordinated with stress-and aging-induced signals.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kevei, Eva UNSPECIFIED orcid.org/0000-0002-0560-9208 UNSPECIFIED Hoppe, Thorsten UNSPECIFIED orcid.org/0000-0002-4734-9352 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-442776
DOI:	10.1038/nsmb.2806
Journal or Publication Title:	Nat. Struct. Mol. Biol.
Volume:	21
Number:	4
Page Range:	S. 290 - 293
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1545-9985
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CAENORHABDITIS-ELEGANS; PROTEIN-DEGRADATION; PROTEASOME ACTIVITY; OXIDATIVE STRESS; SYSTEM; YEAST; NRF2 Multiple languages Biochemistry & Molecular Biology; Biophysics; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/44277