Universität zu Köln

Schultze-Lutter, Frauke, Klosterkoetter, Joachim and Ruhrmann, Stephan ORCID: 0000-0002-6022-2364 (2014). Improving the clinical prediction of psychosis by combining ultra-high risk criteria and cognitive basic symptoms. Schizophr. Res., 154 (1-3). S. 100 - 107. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1573-2509

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Abstract

Objective: Cognitive impairments are regarded as a core component of schizophrenia. However, the cognitive dimension of psychosis is hardly considered by ultra-high risk (UHR) criteria. Therefore, we studied whether the combination of symptomatic UHR criteria and the basic symptom criterion cognitive disturbances (COGDIS) is superior in predicting first-episode psychosis. Method: In a naturalistic 48-month follow-up study, the conversion rate to first-episode psychosis was studied in 246 outpatients of an early detection of psychosis service (FETZ); thereby, the association between conversion, and the combined and singular use of UHR criteria and COGDIS was compared. Results: Patients that met UHR criteria and COGDIS (n=127) at baseline had a significantly higher risk of conversion (hr=0.66 at month 48) and a shorter time to conversion than patients that met only UHR criteria (n=37; hr=0.28) or only COGDIS (n=30; hr=0.23). Furthermore, the risk of conversion was higher for the combined criteria than for UHR criteria (n=164; hr=0.56 at month 48) and COGDIS (n=158; hr=0.56 at month 48) when considered irrespective of each other. Conclusions: Our findings support the merits of considering both COGDIS and UHR criteria in the early detection of persons who are at high risk of developing a first psychotic episode within 48 months. Applying both sets of criteria improves sensitivity and individual risk estimation, and may thereby support the development of stage-targeted interventions. Moreover, since the combined approach enables the identification of considerably more homogeneous at-risk samples, it should support both preventive and basic research. (C) 2014 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schultze-Lutter, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-442936
DOI:	10.1016/j.schres.2014.02.010
Journal or Publication Title:	Schizophr. Res.
Volume:	154
Number:	1-3
Page Range:	S. 100 - 107
Date:	2014
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1573-2509
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERRATER RELIABILITY; 1ST-EPISODE PSYCHOSIS; PRODROMAL STATES; SCHIZOPHRENIA; ADOLESCENTS; IMPAIRMENT; ONSET; YOUTH; POPULATION; PREVENTION Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44293