Universität zu Köln

Horn, Moritz, Geisen, Christoph, Cermak, Lukas ORCID: 0000-0002-8777-3692, Becker, Ben, Nakamura, Shuhei ORCID: 0000-0002-1488-8317, Klein, Corinna, Pagano, Michele and Antebi, Adam (2014). DRE-1/FBXO11-Dependent Degradation of BLMP-1/BLIMP-1 Governs C. elegans Developmental Timing and Maturation. Dev. Cell, 28 (6). S. 697 - 711. CAMBRIDGE: CELL PRESS. ISSN 1878-1551

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Abstract

Developmental timing genes catalyze stem cell progression and animal maturation programs across taxa. Caenorhabditis elegans DRE-1/FBXO11 functions inanSCFE3-ubiquitin ligase complex to regulate the transition to adult programs, but its cognate proteolytic substrates are unknown. Here, we identify the conserved transcription factor BLMP-1 as a substrate of the SCF (DRE-1/FBXO11) complex. blmp-1 deletion suppressed dre-1 mutant phenotypes and exhibited developmental timing defects opposite to dre-1. blmp-1 also opposed dre-1 for other life history traits, including entry into the dauer diapause and longevity. BLMP-1 protein was strikingly elevated upon dre-1 depletion and dysregulated in a stage- and tissue-specific manner. The role of DRE-1 in regulating BLMP-1 stability is evolutionary conserved, as we observed direct protein interaction and degradation function for worm and human counter-parts. Taken together, posttranslational regulation of BLMP-1/BLIMP-1 by DRE-1/FBXO11 coordinates C. elegans developmental timing and other life history traits, suggesting that this two-protein module mediates metazoan maturation processes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Horn, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Geisen, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Cermak, Lukas UNSPECIFIED orcid.org/0000-0002-8777-3692 UNSPECIFIED Becker, Ben UNSPECIFIED UNSPECIFIED UNSPECIFIED Nakamura, Shuhei UNSPECIFIED orcid.org/0000-0002-1488-8317 UNSPECIFIED Klein, Corinna UNSPECIFIED UNSPECIFIED UNSPECIFIED Pagano, Michele UNSPECIFIED UNSPECIFIED UNSPECIFIED Antebi, Adam UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-443049
DOI:	10.1016/j.devcel.2014.01.028
Journal or Publication Title:	Dev. Cell
Volume:	28
Number:	6
Page Range:	S. 697 - 711
Date:	2014
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1878-1551
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GERM-CELL LINEAGE; CAENORHABDITIS-ELEGANS; TERMINAL DIFFERENTIATION; UBIQUITIN LIGASE; OTITIS-MEDIA; GENE; PROTEIN; BLIMP-1; RECEPTOR; NHR-25 Multiple languages Cell Biology; Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44304