Universität zu Köln

Koehler, Karsten ORCID: 0000-0002-9618-2069, Braun, Hans, de Marees, Markus, Geyer, Hans, Thevis, Mario, Mester, Joachim and Schaenzer, Wilhelm (2014). Glycerol administration before endurance exercise: metabolism, urinary glycerol excretion and effects on doping-relevant blood parameters. Drug Test. Anal., 6 (3). S. 202 - 210. HOBOKEN: WILEY. ISSN 1942-7611

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Abstract

Glycerol is prohibited as a masking agent by the World Anti-Doping Agency and a urinary threshold has recently been recommended. However, little is known about urinary glycerol excretion after exercise, when (1) exogenous glycerol is metabolized increasingly and (2) endogenous glycerol levels are elevated. The purpose of the placebo-controlled cross-over study was to determine the effects of pre-exercise glycerol administration on glycerol metabolism, urinary excretion, and selected blood parameters. After administration of glycerol (G; 1.0g/kg body weight (BW)+25ml fluid/kg BW) or placebo (P; 25ml fluid/kg), 14 cyclists exercised 90min at 60% VO2max. Samples were taken at 0h (before administration), 2.5h (before exercise), 4h (after exercise) and 6.5h and additional urine samples were collected until 24h. Exercise increased endogenous plasma glycerol (0.51 +/- 0.21mmol/l) but peak concentrations were much higher in G (2.5h: 15.6 +/- 7.8mmol/l). Urinary glycerol increased rapidly (58,428 +/- 71,084 mu g/ml after 2.5h) and was significantly higher than in P until 13.6 +/- 0.9h (p<0.01). In comparison with placebo administration, G caused significantly greater changes in plasma volume and haemoglobin concentrations after 2.5h. BW and urine production were significantly different between P and G after 2.5h and post-exercise. Despite exercise-induced increases in endogenous glycerol in the control group, urinary excretion remained well below the previously recommended threshold. In addition, exercise-related glycerol degradation did not appear to negatively affect the detection of exogenously administered glycerol. Copyright (c) 2013 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koehler, Karsten UNSPECIFIED orcid.org/0000-0002-9618-2069 UNSPECIFIED Braun, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED de Marees, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Geyer, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Mester, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaenzer, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-444670
DOI:	10.1002/dta.1446
Journal or Publication Title:	Drug Test. Anal.
Volume:	6
Number:	3
Page Range:	S. 202 - 210
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1942-7611
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDUCED HYPERHYDRATION; PERFORMANCE; INSULIN; FAT Multiple languages Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44467