Universität zu Köln

Jung, Heike, Land, Christof, Blum, Werner F. and Schoeenau, Eckhard (2014). Early differentiation between good and poor response to growth hormone therapy in short children born small for gestational age (SGA) to improve the outcome of poor responders. J. Pediatr. Endocrinol. Metab., 27 (3-4). S. 229 - 236. BERLIN: WALTER DE GRUYTER GMBH. ISSN 2191-0251

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Abstract

Objective: The aim of this study was to examine heigh-tgain response in relation to predicted good or poor response during first-year low or high growth hormone (GH) dose in short prepubertal children born small for gestational age. Patients and methods: The OPTIMA (Optimization of GH Treatment in Short Children Born Small for Gestational Age Based on a Growth Prediction Model) randomised study evaluated 12-month height standard deviation score (SDS) changes in patients receiving GH dose: fixed high (FH; 0.067 mg/kg/day) or 0.035 mg/kg/day individually adjusted (IA) after 3 months according to the Cologne early growth prediction. Results: Predicted 12-month height SDS gain was < 0.75 for 21/89 FH-dose patients, considered poor responders; 11/21 reached a 12-month height SDS gain of >= 0.75. In IA-dose poor responders, increasing GH dose at 3 months maintained mean height velocity (HV), with 73.7% reaching a 12-month height SDS gain of = 0.75 vs. 73.8% in IA-dose good responders who continued on low GH dose, where mean HV decreased after the initial 3-month period. Conclusion: GH dose increase at 3 months in patients with predicted poor response maintained catch-up growth. Even when on FH dose, some patients did not achieve a good response.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jung, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Land, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Blum, Werner F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoeenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-444763
DOI:	10.1515/jpem-2013-0155
Journal or Publication Title:	J. Pediatr. Endocrinol. Metab.
Volume:	27
Number:	3-4
Page Range:	S. 229 - 236
Date:	2014
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	2191-0251
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IDIOPATHIC SHORT STATURE; GH TREATMENT; PREPUBERTAL CHILDREN; PREDICTION MODEL; ADULT HEIGHT; DEFICIENCY; RETARDATION; VALIDATION; DATABASE; BIRTH Multiple languages Endocrinology & Metabolism; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44476