Behrens, Axel ORCID: 0000-0002-1557-1143, van Deursen, Jan M., Rudolph, K. Lenhard and Schumacher, Bjoern
(2014).
Impact of genomic damage and ageing on stem cell function.
Nat. Cell Biol., 16 (3).
S. 201 - 208.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 1476-4679
Abstract
Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.
Item Type: | Journal Article | ||||||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-445492 | ||||||||||||||||||||
DOI: | 10.1038/ncb2928 | ||||||||||||||||||||
Journal or Publication Title: | Nat. Cell Biol. | ||||||||||||||||||||
Volume: | 16 | ||||||||||||||||||||
Number: | 3 | ||||||||||||||||||||
Page Range: | S. 201 - 208 | ||||||||||||||||||||
Date: | 2014 | ||||||||||||||||||||
Publisher: | NATURE PUBLISHING GROUP | ||||||||||||||||||||
Place of Publication: | LONDON | ||||||||||||||||||||
ISSN: | 1476-4679 | ||||||||||||||||||||
Language: | English | ||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||
Uncontrolled Keywords: |
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URI: | http://kups.ub.uni-koeln.de/id/eprint/44549 |
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