Universität zu Köln

Preller, Katrin H., Herdener, Marcus ORCID: 0000-0001-5830-1971, Schilbach, Leonhard ORCID: 0000-0001-5547-8309, Staempfli, Philipp, Hulka, Lea M., Vonmoos, Matthias, Ingold, Nina, Vogeley, Kai, Tobler, Philippe N., Seifritz, Erich and Quednow, Boris B. ORCID: 0000-0001-7933-2865 (2014). Functional changes of the reward system underlie blunted response to social gaze in cocaine users. Proc. Natl. Acad. Sci. U. S. A., 111 (7). S. 2842 - 2848. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

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Abstract

Social interaction deficits in drug users likely impede treatment, increase the burden of the affected families, and consequently contribute to the high costs for society associated with addiction. Despite its significance, the neural basis of altered social interaction in drug users is currently unknown. Therefore, we investigated basal social gaze behavior in cocaine users by applying behavioral, psychophysiological, and functional brain-imaging methods. In study I, 80 regular cocaine users and 63 healthy controls completed an interactive paradigm in which the participants' gaze was recorded by an eye-tracking device that controlled the gaze of an anthropomorphic virtual character. Valence ratings of different eye-contact conditions revealed that cocaine users show diminished emotional engagement in social interaction, which was also supported by reduced pupil responses. Study II investigated the neural underpinnings of changes in social reward processing observed in study I. Sixteen cocaine users and 16 controls completed a similar interaction paradigm as used in study I while undergoing functional magnetic resonance imaging. In response to social interaction, cocaine users displayed decreased activation of the medial orbitofrontal cortex, a key region of reward processing. Moreover, blunted activation of the medial orbitofrontal cortex was significantly correlated with a decreased social network size, reflecting problems in real-life social behavior because of reduced social reward. In conclusion, basic social interaction deficits in cocaine users as observed here may arise from altered social reward processing. Consequently, these results point to the importance of reinstatement of social reward in the treatment of stimulant addiction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Preller, Katrin H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herdener, Marcus UNSPECIFIED orcid.org/0000-0001-5830-1971 UNSPECIFIED Schilbach, Leonhard UNSPECIFIED orcid.org/0000-0001-5547-8309 UNSPECIFIED Staempfli, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Hulka, Lea M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vonmoos, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Ingold, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogeley, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Tobler, Philippe N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seifritz, Erich UNSPECIFIED UNSPECIFIED UNSPECIFIED Quednow, Boris B. UNSPECIFIED orcid.org/0000-0001-7933-2865 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-445813
DOI:	10.1073/pnas.1317090111
Journal or Publication Title:	Proc. Natl. Acad. Sci. U. S. A.
Volume:	111
Number:	7
Page Range:	S. 2842 - 2848
Date:	2014
Publisher:	NATL ACAD SCIENCES
Place of Publication:	WASHINGTON
ISSN:	0027-8424
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ORBITOFRONTAL CORTEX; JOINT ATTENTION; ADOLESCENT ALCOHOL; FEAR RECOGNITION; DECISION-MAKING; IMPULSE CONTROL; PUPIL SIZE; DRUG-USE; ADDICTION; DYSFUNCTION Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44581