Universität zu Köln

Ahuja, Gaurav, Nia, Shahrzad Bozorg, Zapilko, Veronika, Shiriagin, Vladimir, Kowatschew, Daniel, Oka, Yuichiro and Korsching, Sigrun I. ORCID: 0000-0002-5450-172X (2014). Kappe neurons, a novel population of olfactory sensory neurons. Sci Rep, 4. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Perception of olfactory stimuli is mediated by distinct populations of olfactory sensory neurons, each with a characteristic set of morphological as well as functional parameters. Beyond two large populations of ciliated and microvillous neurons, a third population, crypt neurons, has been identified in teleost and cartilaginous fishes. We report here a novel, fourth olfactory sensory neuron population in zebrafish, which we named kappe neurons for their characteristic shape. Kappe neurons are identified by their G(o)-like immunoreactivity, and show a distinct spatial distribution within the olfactory epithelium, similar to, but significantly different from that of crypt neurons. Furthermore, kappe neurons project to a single identified target glomerulus within the olfactory bulb, mdg5 of the mediodorsal cluster, whereas crypt neurons are known to project exclusively to the mdg2 glomerulus. Kappe neurons are negative for established markers of ciliated, microvillous and crypt neurons, but appear to have microvilli. Kappe neurons constitute the fourth type of olfactory sensory neurons reported in teleost fishes and their existence suggests that encoding of olfactory stimuli may require a higher complexity than hitherto assumed already in the peripheral olfactory system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ahuja, Gaurav UNSPECIFIED UNSPECIFIED UNSPECIFIED Nia, Shahrzad Bozorg UNSPECIFIED UNSPECIFIED UNSPECIFIED Zapilko, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Shiriagin, Vladimir UNSPECIFIED UNSPECIFIED UNSPECIFIED Kowatschew, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Oka, Yuichiro UNSPECIFIED UNSPECIFIED UNSPECIFIED Korsching, Sigrun I. UNSPECIFIED orcid.org/0000-0002-5450-172X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-445977
DOI:	10.1038/srep04037
Journal or Publication Title:	Sci Rep
Volume:	4
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ZEBRAFISH DANIO-RERIO; ADULT ZEBRAFISH; CRYPT NEURONS; RECEPTOR; EPITHELIUM; SYSTEM; IMMUNOREACTIVITY; PHOTORECEPTORS; MICROVILLI; GLOMERULI Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/44597