Universität zu Köln

Grammatikos, Georgios, Lange, Christian, Susser, Simone, Schwendy, Susanne, Dikopoulos, Nektarios, Buggisch, Peter, Encke, Jens, Teuber, Gerlinde, Goeser, Tobias, Thimme, Robert, Klinker, Hartwig, Boecher, Wulf O., Schulte-Frohlinde, Ewert, Penna-Martinez, Marissa, Badenhoop, Klaus, Zeuzem, Stefan, Berg, Thomas ORCID: 0000-0003-0003-6241 and Sarrazin, Christoph (2014). Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients. PLoS One, 9 (2). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Full text not available from this repository.

Abstract

Background: Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance of vitamin D levels are conflicting. In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has been performed. Methods: In a well characterized prospective cohort of 398 genotype 1 infected patients treated with pegylated interferon-alpha and ribavirin for 24-72 weeks (INDIV-2 study) 25-OH-vitamin D levels and different single nucleotide polymorphisms were analyzed together with known biochemical parameters for a correlation with virologic treatment outcome. Results: Fluctuations of more than 5 (10) ng/ml in 25-OH-vitamin D-levels have been observed in 66 (39) % of patients during the course of antiviral therapy and neither pretreatment nor under treatment 25-OH-vitamin D-levels were associated with treatment outcome. The DHCR7-TT-polymorphism within the 7-dehydrocholesterol-reductase showed a significant association (P = 0.031) to sustained viral response in univariate analysis. Among numerous further parameters analyzed we found that age (OR = 1.028, CI = 1.002-1.056, P = 0.035), cholesterol (OR = 0.983, CI = 0.975-0.991, P<0.001), ferritin (OR = 1.002, CI = 1.000-1.004, P = 0.033), gGT (OR = 1.467, CI = 1.073-2.006, P = 0.016) and IL28B-genotype (OR = 2.442, CI = 1.271-4.695, P = 0.007) constituted the strongest predictors of treatment response. Conclusions: While 25-OH-vitamin D-levels levels show considerable variations during the long-lasting course of antiviral therapy they do not show any significant association to treatment outcome in genotype 1 infected patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grammatikos, Georgios UNSPECIFIED UNSPECIFIED UNSPECIFIED Lange, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Susser, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwendy, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Dikopoulos, Nektarios UNSPECIFIED UNSPECIFIED UNSPECIFIED Buggisch, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Encke, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Teuber, Gerlinde UNSPECIFIED UNSPECIFIED UNSPECIFIED Goeser, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Thimme, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Klinker, Hartwig UNSPECIFIED UNSPECIFIED UNSPECIFIED Boecher, Wulf O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulte-Frohlinde, Ewert UNSPECIFIED UNSPECIFIED UNSPECIFIED Penna-Martinez, Marissa UNSPECIFIED UNSPECIFIED UNSPECIFIED Badenhoop, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeuzem, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Thomas UNSPECIFIED orcid.org/0000-0003-0003-6241 UNSPECIFIED Sarrazin, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-445998
DOI:	10.1371/journal.pone.0087974
Journal or Publication Title:	PLoS One
Volume:	9
Number:	2
Date:	2014
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC HEPATITIS-C; SUSTAINED VIROLOGICAL RESPONSE; COMMON GENETIC-DETERMINANTS; D SERUM-LEVELS; IL28B POLYMORPHISMS; INTERFERON-ALPHA; VIRAL CLEARANCE; VIRUS-INFECTION; SEVERE FIBROSIS; D INSUFFICIENCY Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44599