Sayou, Camille ORCID: 0000-0002-8226-7272, Monniaux, Marie ORCID: 0000-0001-6847-3902, Nanao, Max H., Moyroud, Edwige ORCID: 0000-0001-7908-3205, Brockington, Samuel F., Thevenon, Emmanuel, Chahtane, Hicham ORCID: 0000-0002-0976-1186, Warthmann, Norman ORCID: 0000-0002-1178-8409, Melkonian, Michael, Zhang, Yong, Wong, Gane Ka-Shu, Weigel, Detlef ORCID: 0000-0002-2114-7963, Parcy, Francois ORCID: 0000-0003-2191-500X and Dumas, Renaud (2014). A Promiscuous Intermediate Underlies the Evolution of LEAFY DNA Binding Specificity. Science, 343 (6171). S. 645 - 649. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

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Abstract

Transcription factors (TFs) are key players in evolution. Changes affecting their function can yield novel life forms but may also have deleterious effects. Consequently, gene duplication events that release one gene copy from selective pressure are thought to be the common mechanism by which TFs acquire new activities. Here, we show that LEAFY, a major regulator of flower development and cell division in land plants, underwent changes to its DNA binding specificity, even though plant genomes generally contain a single copy of the LEAFY gene. We examined how these changes occurred at the structural level and identify an intermediate LEAFY form in hornworts that appears to adopt all different specificities. This promiscuous intermediate could have smoothed the evolutionary transitions, thereby allowing LEAFY to evolve new binding specificities while remaining a single-copy gene.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sayou, CamilleUNSPECIFIEDorcid.org/0000-0002-8226-7272UNSPECIFIED
Monniaux, MarieUNSPECIFIEDorcid.org/0000-0001-6847-3902UNSPECIFIED
Nanao, Max H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moyroud, EdwigeUNSPECIFIEDorcid.org/0000-0001-7908-3205UNSPECIFIED
Brockington, Samuel F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thevenon, EmmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chahtane, HichamUNSPECIFIEDorcid.org/0000-0002-0976-1186UNSPECIFIED
Warthmann, NormanUNSPECIFIEDorcid.org/0000-0002-1178-8409UNSPECIFIED
Melkonian, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, YongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wong, Gane Ka-ShuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weigel, DetlefUNSPECIFIEDorcid.org/0000-0002-2114-7963UNSPECIFIED
Parcy, FrancoisUNSPECIFIEDorcid.org/0000-0003-2191-500XUNSPECIFIED
Dumas, RenaudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-446000
DOI: 10.1126/science.1248229
Journal or Publication Title: Science
Volume: 343
Number: 6171
Page Range: S. 645 - 649
Date: 2014
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication: WASHINGTON
ISSN: 1095-9203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
REGULATOR; DIVERSITYMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/44600

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