Lechartier, Benoit, Rybniker, Jan, Zumla, Alimuddin and Cole, Stewart T. (2014). Tuberculosis drug discovery in the post-post-genomic era. EMBO Mol. Med., 6 (2). S. 158 - 169. HOBOKEN: WILEY. ISSN 1757-4684
Full text not available from this repository.Abstract
The expectation that genomics would result in new therapeutic interventions for infectious diseases remains unfulfilled. In the post-genomic era, the decade immediately following the availability of the genome sequence of Mycobacterium tuberculosis, tuberculosis (TB) drug discovery relied heavily on the target-based approach but this proved unsuccessful leading to a return to whole cell screening. Genomics underpinned screening by providing knowledge and many enabling technologies, most importantly whole genome resequencing to find resistance mutations and targets, and this resulted in a selection of leads and new TB drug candidates that are reviewed here. Unexpectedly, many new targets were found to be promiscuous' as they were inhibited by a variety of different compounds. In the post-post-genomics era, more advanced technologies have been implemented and these include high-content screening, screening for inhibitors of latency, the use of conditional knock-down mutants for validated targets and siRNA screens. In addition, immunomodulation and pharmacological manipulation of host functions are being explored in an attempt to widen our therapeutic options.
Item Type: | Journal Article | ||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-447007 | ||||||||||||||||||||
DOI: | 10.1002/emmm.201201772 | ||||||||||||||||||||
Journal or Publication Title: | EMBO Mol. Med. | ||||||||||||||||||||
Volume: | 6 | ||||||||||||||||||||
Number: | 2 | ||||||||||||||||||||
Page Range: | S. 158 - 169 | ||||||||||||||||||||
Date: | 2014 | ||||||||||||||||||||
Publisher: | WILEY | ||||||||||||||||||||
Place of Publication: | HOBOKEN | ||||||||||||||||||||
ISSN: | 1757-4684 | ||||||||||||||||||||
Language: | English | ||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/44700 |
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