Universität zu Köln

Koch, Manja ORCID: 0000-0002-4794-4821, Borggrefe, Jan ORCID: 0000-0003-2908-7560, Barbaresko, Janett ORCID: 0000-0003-0855-2769, Groth, Godo, Jacobs, Gunnar, Siegert, Sabine, Lieb, Wolfgang, Mueller, Manfred James, Bosy-Westphal, Anja, Heller, Martin and Noethlings, Ute (2014). Dietary patterns associated with magnetic resonance imaging-determined liver fat content in a general population study. Am. J. Clin. Nutr., 99 (2). S. 369 - 378. BETHESDA: AMER SOC NUTRITION-ASN. ISSN 1938-3207

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Abstract

Background: The association between diet and fatty liver disease (FLD) has predominantly been analyzed for single nutrients or foods, and findings have been inconsistent. Objective: We aimed to compare associations of hypothesis-driven and exploratory dietary pattern scores with liver fat content. Design: Liver fat was measured by using magnetic resonance imaging as liver signal intensity (LSI) in a population-based, crosssectional study that included 354 individuals. We applied partial least-squares regression to derive an exploratory dietary pattern score that explained variation in both the intake of 38 food groups, which were assessed by using a food-frequency questionnaire, and LSI. The hypothesis-driven score was calculated on the basis of published studies. Multivariable linear or logistic regression was used to investigate associations between dietary pattern scores and LSI or FLD. Results: A higher percentage of LSI variation was explained by the exploratory (12.6%) compared with the hypothesis-driven (2.2%) dietary pattern. Of the 13 most important food groups of the exploratory dietary pattern, intakes of green and black tea, soups, and beer were also individually associated with LSI values. A 1-unit increase in the exploratory dietary pattern score was positively associated with FLD (OR: 1.56; 95% CI: 1.29, 1.88). Furthermore, a 1-unit increase in the hypothesis-driven dietary pattern score, which consisted of alcohol, soft drinks, meat, coffee, and tea, was positively associated with FLD (OR: 1.25; 95% CI: 1.10, 1.43). Conclusion: We defined a hypothesis-driven dietary pattern and derived an exploratory dietary pattern, both of which included alcohol, meat (poultry), and tea, associated with liver fat content independent from confounders, which should be explored in prospective studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koch, Manja UNSPECIFIED orcid.org/0000-0002-4794-4821 UNSPECIFIED Borggrefe, Jan UNSPECIFIED orcid.org/0000-0003-2908-7560 UNSPECIFIED Barbaresko, Janett UNSPECIFIED orcid.org/0000-0003-0855-2769 UNSPECIFIED Groth, Godo UNSPECIFIED UNSPECIFIED UNSPECIFIED Jacobs, Gunnar UNSPECIFIED UNSPECIFIED UNSPECIFIED Siegert, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Lieb, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Manfred James UNSPECIFIED UNSPECIFIED UNSPECIFIED Bosy-Westphal, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Heller, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Noethlings, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-447262
DOI:	10.3945/ajcn.113.070219
Journal or Publication Title:	Am. J. Clin. Nutr.
Volume:	99
Number:	2
Page Range:	S. 369 - 378
Date:	2014
Publisher:	AMER SOC NUTRITION-ASN
Place of Publication:	BETHESDA
ISSN:	1938-3207
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FOOD FREQUENCY QUESTIONNAIRE; CORONARY-ARTERY-DISEASE; PARTIAL LEAST-SQUARES; NUTRITIONAL EPIDEMIOLOGY; METABOLIC SYNDROME; TEA CONSUMPTION; VISCERAL FAT; GREEN TEA; PREVALENCE; FIBROSIS Multiple languages Nutrition & Dietetics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44726