Universität zu Köln

Schultheis, Anne M., Bos, Marc, Schmitz, Katja, Wilsberg, Lea, Binot, Elke, Wolf, Juergen, Buettner, Reinhard and Schildhaus, Hans-Ulrich (2014). Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer. Mod. Pathol., 27 (2). S. 214 - 222. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1530-0285

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Abstract

Small-cell lung cancer (SCLC) comprises about 13-15% of all lung cancers, and more than 29400 new cases have been diagnosed in the United States in the year 2012. SCLC is a biologically complex tumor typically occurring in heavy smokers. Its medical treatment has almost remained unchanged over the last decades and selected treatment options have not been established so far, mainly due to the lack of targetable genetic alterations. In this study we analyzed a cohort of 307 SCLC samples for fibroblast growth factor receptor 1 (FGFR1) amplification using a dual color FISH probe. FGFR1 status was correlated with clinical data. FGFR1 amplifications were observed in 5.6% of evaluable pulmonary SCLCs. Most of them (93%) fulfilled the criteria for high-level amplification and only one case showed low-level amplification. Amplification patterns were homogenous in the entire tumor area without occurrence of any 'hot spot' areas. FGFR1 amplification status was not associated with age, sex, stage, smoking status or overall survival. FGFR1 amplification analysis by FISH analysis in SCLC is, under respect of certain technical issues, applicable in the routine clinical setting. However, the FGFR1 amplification patterns in SCLC differs strongly from the previously described FGFR1 amplification pattern in squamous cell carcinoma of the lung, as positive SCLC harbor mostly homogeneous high-level amplifications. We provide evidence that an estimated number of 1640 newly diagnosed FGFR1-positive SCLC cases in the United States annually could benefit from targeted therapy. Therefore, we recommend including SCLC in the screening for ongoing clinical trials with FGFR1 inhibitors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schultheis, Anne M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bos, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilsberg, Lea UNSPECIFIED UNSPECIFIED UNSPECIFIED Binot, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildhaus, Hans-Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-447730
DOI:	10.1038/modpathol.2013.141
Journal or Publication Title:	Mod. Pathol.
Volume:	27
Number:	2
Page Range:	S. 214 - 222
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1530-0285
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IDENTIFICATION; SURVIVAL; GENE Multiple languages Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44773