Borchmann, Peter (2014). Early Intensification Treatment Approach in Advanced-stage Hodgkin Lymphoma. Hematol. Oncol. Clin. North Am., 28 (1). S. 65 - 76. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC. ISSN 1558-1977
Full text not available from this repository.Abstract
The key question in advanced-stage Hodgkin lymphoma for many years now has been, should intensified chemotherapy be applied upfront or be reserved for relapsing patients. The early intensification approach with BEACOPP escalated (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) aims at curing patients with first-line chemotherapy definitely. The added toxicity of this approach as compared to less intensive regimens as ABDV (doxorubicin, bleomycin, dacarbazine, vinblastine) is mainly restricted to acute haematotoxicity and gonadal damage. However, regarding efficacy, there is a meaningful survival-benefit over ABVD (10% at 5 years) and the intensified first-line treatment strategy is thus rightly regarded as standard of care.
| Item Type: | Journal Article | ||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-447976 | ||||||||
| DOI: | 10.1016/j.hoc.2013.10.002 | ||||||||
| Journal or Publication Title: | Hematol. Oncol. Clin. North Am. | ||||||||
| Volume: | 28 | ||||||||
| Number: | 1 | ||||||||
| Page Range: | S. 65 - 76 | ||||||||
| Date: | 2014 | ||||||||
| Publisher: | W B SAUNDERS CO-ELSEVIER INC | ||||||||
| Place of Publication: | PHILADELPHIA | ||||||||
| ISSN: | 1558-1977 | ||||||||
| Language: | English | ||||||||
| Faculty: | Unspecified | ||||||||
| Divisions: | Unspecified | ||||||||
| Subjects: | no entry | ||||||||
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/44797 |
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