Universität zu Köln

Schenten, Dominik, Nish, Simone A., Yu, Shuang, Yan, Xiting, Lee, Heung Kyu ORCID: 0000-0002-3977-1510, Brodsky, Igor, Pasman, Lesley, Yordy, Brian, Wunderlich, F. Thomas, Bruening, Jens C., Zhao, Hongyu and Medzhitov, Ruslan (2014). Signaling through the Adaptor Molecule MyD88 in CD4(+) T Cells Is Required to Overcome Suppression by Regulatory T Cells. Immunity, 40 (1). S. 78 - 91. CAMBRIDGE: CELL PRESS. ISSN 1097-4180

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Abstract

Innate immune recognition controls adaptive immune responses through multiple mechanisms. The MyD88 signaling adaptor operates in many cell types downstream of Toll-like receptors (TLRs) and interleukin-1 (IL-1) receptor family members. Cell-type-specific functions of MyD88 signaling remain poorly characterized. Here, we have shown that the T cell-specific ablation of MyD88 in mice impairs not only T helper 17 (Th17) cell responses, but also Th1 cell responses. MyD88 relayed signals of TLR-induced IL-1, which became dispensable for Th1 cell responses in the absence of T regulatory (Treg) cells. Treg cell-specific ablation of MyD88 had no effect, suggesting that IL-1 acts on naive CD4(+) T cells instead of Treg cells themselves. Together, these findings demonstrate that IL-1 renders naive CD4(+) T cells refractory to Treg cell-mediated suppression in order to allow their differentiation into Th1 cells. In addition, IL-1 was also important for the generation of functional CD4(+) memory T cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schenten, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Nish, Simone A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yu, Shuang UNSPECIFIED UNSPECIFIED UNSPECIFIED Yan, Xiting UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, Heung Kyu UNSPECIFIED orcid.org/0000-0002-3977-1510 UNSPECIFIED Brodsky, Igor UNSPECIFIED UNSPECIFIED UNSPECIFIED Pasman, Lesley UNSPECIFIED UNSPECIFIED UNSPECIFIED Yordy, Brian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wunderlich, F. Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Hongyu UNSPECIFIED UNSPECIFIED UNSPECIFIED Medzhitov, Ruslan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-448446
DOI:	10.1016/j.immuni.2013.10.023
Journal or Publication Title:	Immunity
Volume:	40
Number:	1
Page Range:	S. 78 - 91
Date:	2014
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1097-4180
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INNATE IMMUNE-SYSTEM; TOLL-LIKE RECEPTORS; MEDIATED SUPPRESSION; RESPONSE LATE; CUTTING EDGE; BURN INJURY; IL-1; EXPRESSION; EXPANSION; DIFFERENTIATION Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44844