Universität zu Köln

Oros-Peusquens, A. -M., Keil, F., Langen, K. J., Herzog, H., Stoffels, G., Weiss, C. and Shah, N. J. (2014). Fast and accurate water content and T2*mapping in brain tumours localised with FET-PET. Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip., 734. S. 185 - 191. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-9576

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Abstract

The availability of combined MR-PET scanners opens new opportunities for the characterisation of tumour environment. In this study, water content and relaxation properties of glioblastoma were investigated in five patients using advanced MRI. The region containing metabolically active tumour tissue was defined by simultaneously measured FET-PET uptake. The mean value of water content in tumour tissue - obtained noninvasively with high precision and accuracy for the first time - amounted to 84.5%, similar to the value for normal grey matter. Constancy of water content contrasted with a large variability of T2* values in tumour tissue, qualitatively related to the magnetic inhomogeneity of tissue created by blood vessels and/or microbleeds. The quantitative MRI protocol takes 71/2 min of measurement time and is proposed for extended clinical use. (C) 2013 Elsevier BM. All rights reserved

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Oros-Peusquens, A. -M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Keil, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, K. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herzog, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffels, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, N. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-448564
DOI:	10.1016/j.nima.2013.09.045
Journal or Publication Title:	Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip.
Volume:	734
Page Range:	S. 185 - 191
Date:	2014
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1872-9576
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUANTITATIVE MRI; IN-VIVO; GLIOMAS; FIELD Multiple languages Instruments & Instrumentation; Nuclear Science & Technology; Physics, Nuclear; Physics, Particles & Fields Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44856