Universität zu Köln

Karlstetter, Marcus and Langmann, Thomas (2014). Microglia in the Aging Retina. S. 207 - 213. BERLIN: SPRINGER-VERLAG BERLIN. ISSN 2214-8019

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Abstract

In the healthy retina, microglial cells represent a self-renewing population of innate immune cells, which constantly survey their microenvironment. Equipped with receptors, a microglial cell detects subtle cellular damage and rapidly responds with activation, migration, and increased phagocytic activity. While the involvement of microglial cells has been well characterized in monogenic retinal disorders, it is still unclear how they contribute to the onset of retinal aging disorders including age-related macular degeneration (AMD). There is evidence, that microglial activation is not solely a secondary manifestation of retinal tissue damage in age-related disorders. Thus, work in the aging rodent and human retina suggests that long-lived and genetically predisposed microglia transform into a dystrophic state, with loss of neuroprotective functions. In this concept, malfunction of aging microglia can trigger a chronic low-grade inflammatory environment that favors the onset and progression of retinal degeneration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Karlstetter, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Langmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-448985
DOI:	10.1007/978-1-4614-3209-8_27
Title of Book:	Advances in Experimental Medicine and Biology
Series Name:	Adv.Exp.Med.Biol.
Volume:	801
Page Range:	S. 207 - 213
Date:	2014
Publisher:	SPRINGER-VERLAG BERLIN
Place of Publication:	BERLIN
ISSN:	2214-8019
ISBN:	978-1-4614-3209-8; 978-1-4614-3208-1
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVATION; DEGENERATION; CELLS; MICE Multiple languages Biology; Medicine, Research & Experimental; Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44898