Universität zu Köln

Peti-Peterdi, Janos ORCID: 0000-0003-4092-6185, Burford, James L. and Hackl, Matthias J. (2014). Can Kidney Regeneration Be Visualized? Nephron Exp. Nephrol, 126 (2). S. 86 - 91. BASEL: KARGER. ISSN 1660-2129

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Abstract

Background: Various cell types, including podocytes and parietal epithelial cells, play important roles in the development and progression of glomerular kidney diseases, albuminuria, and glomerulosclerosis. Besides their role in renal pathologies, glomerular cells have emerging new functions in endogenous repair mechanisms. A better understanding of the dynamics of the glomerular environment and cellular composition in an intact living kidney is critically important for the development of new regenerative therapeutic strategies for kidney diseases: However, progress in this field has been hampered by the lack of in vivo research tools. Summary: This review summarizes the current state-of-the-art in the application of the unique intravital imaging technology of multiphoton fluorescence microscopy for the dynamic visualization of glomerular structure and function over time in the intact, living kidney. Recently, this imaging approach in combination with transgenic mouse models allowed tracking of the fate of individual glomerular cells in vivo over several days and depicted the highly dynamic nature of the glomerular environment, particularly in disease conditions. Key Messages: The technology is ready and available for future intravital imaging studies investigating new glomerular regenerative approaches in animal models. (C) 2014 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Peti-Peterdi, Janos UNSPECIFIED orcid.org/0000-0003-4092-6185 UNSPECIFIED Burford, James L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hackl, Matthias J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-450336
DOI:	10.1159/000360673
Journal or Publication Title:	Nephron Exp. Nephrol
Volume:	126
Number:	2
Page Range:	S. 86 - 91
Date:	2014
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1660-2129
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PARIETAL EPITHELIAL-CELLS; MULTIPHOTON MICROSCOPY; RENAL PROGENITORS; PODOCYTE; RECRUITMENT; LINEAGE; DISEASE; INJURY Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45033