Universität zu Köln

JayaNandanan, N., Mathew, Renjith and Leptin, Maria ORCID: 0000-0001-7097-348X (2014). Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin. Nat. Commun., 5. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Full text not available from this repository.

Abstract

Apical membranes in many polarized epithelial cells show specialized morphological adaptations that fulfil distinct physiological functions. The air-transporting tubules of Drosophila tracheal terminal cells represent an extreme case of membrane specialization. Here we show that Bitesize (Btsz), a synaptotagmin-like protein family member, is needed for luminal membrane morphogenesis. Unlike in multicellular tubes and other epithelia, where it influences apical integrity by affecting adherens junctions, Btsz here acts at a distance from junctions. Localized at the luminal membrane through its tandem C2 domain, it recruits activated Moesin. Both proteins are needed for the integrity of the actin cytoskeleton at the luminal membrane, but not for other pools of F-actin in the cell, nor do actin-dependent processes at the outer membrane, such as filopodial activity or membrane growth depend on Btsz. Btsz and Moesin guide luminal membrane morphogenesis through organizing actin and allowing the incorporation of membrane containing the apical determinant Crumbs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code JayaNandanan, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathew, Renjith UNSPECIFIED UNSPECIFIED UNSPECIFIED Leptin, Maria UNSPECIFIED orcid.org/0000-0001-7097-348X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-450844
DOI:	10.1038/ncomms4036
Journal or Publication Title:	Nat. Commun.
Volume:	5
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DROSOPHILA TRACHEAL DEVELOPMENT; APICAL MEMBRANE; BRANCHING MORPHOGENESIS; TUBE MORPHOGENESIS; CELL INTERCALATION; EPITHELIAL-CELLS; REQUIRES; POLARITY; NETWORK; SYSTEM Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/45084