Universität zu Köln

Tatsuta, Takashi, Scharwey, Melanie and Langer, Thomas ORCID: 0000-0003-1250-1462 (2014). Mitochondrial lipid trafficking. Trends Cell Biol., 24 (1). S. 44 - 53. LONDON: ELSEVIER SCIENCE LONDON. ISSN 0962-8924

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Abstract

Mitochondria are dynamic organelles surrounded by two membranes with a defined lipid composition. The majority of lipids are synthesized in the endoplasmic reticulum (ER) and transported to the mitochondria, but the synthesis of cardiolipin and phosphatidylethanolamine in the inner membrane of mitochondria highlights their general importance for cellular lipid metabolism. Extensive exchange of lipids and their precursors occurs between the ER and mitochondria as well as between mitochondria! membranes. The recent identification of membrane-tethering complexes and lipid-transfer proteins in mitochondria now provides the first insight into the mechanisms of these transport processes, which are of fundamental importance for mitochondrial activities and cell homeostasis. Here, we summarize the current understanding of lipid trafficking at the mitochondria and discuss emerging models for the mechanisms of lipid transfer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tatsuta, Takashi UNSPECIFIED UNSPECIFIED UNSPECIFIED Scharwey, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Langer, Thomas UNSPECIFIED orcid.org/0000-0003-1250-1462 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-451065
DOI:	10.1016/j.tcb.2013.07.011
Journal or Publication Title:	Trends Cell Biol.
Volume:	24
Number:	1
Page Range:	S. 44 - 53
Date:	2014
Publisher:	ELSEVIER SCIENCE LONDON
Place of Publication:	LONDON
ISSN:	0962-8924
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEMBRANE CONTACT SITES; SACCHAROMYCES-CEREVISIAE; TRANSBILAYER MOVEMENT; ENDOPLASMIC-RETICULUM; INTERMEMBRANE SPACE; OUTER-MEMBRANE; INTRAMITOCHONDRIAL TRANSPORT; PHOSPHATIDYLSERINE TRANSPORT; BINDING PROTEINS; MAMMALIAN-CELLS Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45106